Roles of the Phosphorylation of Transcriptional Factors in Epithelial-Mesenchymal Transition

Table 2

The posttranslational modification sites of Slug for EMT.

Residues-modification	Kinase/Enzyme	Function	Cancer Type	Reference
Phosphorylation
S158/S254-p	PAK4	Stabilization	Prostate	[31]
		TF activity
S87/S104-p	ERK2	TF activity	Breast	[32]
S54/S104-p	Cyclin	Degradation	Lung	[33]
	E/CDK2
S92/S96/S100/S104-p	GSK-3β	Degradation	Non-small cell lung	[34]
		Degradation	Breast	[35]
		Degradation	Liver, breast	[36]
S247/S251/S254-p	PAK1	Stabilization	Breast, bladder	[37]
Acetylation
K8/K116-Ac	Deacetylase	Stabilization	Basal-like	[38]
	SIRT2		breast