Journal of Oncology

Research Article

Characteristics of Peripheral Immune Function in Reproductive Females with Uterine Leiomyoma

Table 2

Partial correlation analysis and stratification analysis controlling the confounding factor age (n = 30).


Clinical phenotypes/immune indexes	Uncontrolled Spearman correlation	Controlled³ partial correlation	≤35 stratification analysis	>35 stratification analysis

Menstrual cycle, days
CD4CM (% of CD4 T cell)	−0.395, 0.031	−0.005, 0.979	−0.306, 0.309	−0.240, 0.353
Th2 (% of Th cells)	−0.488, 0.006	−0.367, 0.051	−0.163, 0.595	−0.731, 0.001
Tfh (% of lymphocyte)	−0.433, 0.017	−0.280, 0.226	−0.550, 0.051	−0.425, 0.089

Menstrual duration, days
Tfh1/Tfh2	0.389, 0.028	0.375, 0.045	0.032, 0.918	0.461, 0.062
CD56+NKP46+ (% of lymphocyte)	−0.409, 0.025	−0.295, 0.121	−0.218, 0.474	−0.375, 0.139

Number of myomas
Tfh1/Tfh2	0.260, 0.017	0.437, 0.020	0.081, 0.768	0.556, 0.250
Tfh17 (% of lymphocyte)	0.413, 0.026	0.445, 0.018	0.504, 0.079	0.265, 0.322

Diameter of myoma¹
CD8EMRACD127^high (% of CD8 EMRA)	0.390, 0.033	0.350, 0.063	0.302, 0.316	0.471, 0.056

Pelvic lesions (Mann–whitney U)²
Tfh1 (% of lymphocyte)	−2.061, 0.037	—	−0.268, 0.789	−1.860, 0.063

RBC
Treg (% of lymphocyte)	−0.411, 0.024	−0.286, 0.132	−0.407, 0.167	−0.430, 0.085
CD56+NKG2D+ (% of lymphocyte)	0.417, 0.022	0.209, 0.276	0.305, 0.310	0.314, 0.220

Hb
Tc1 (% of Tc)	0.405, 0.027	0.360, 0.055	0.556, 0.049	0.292, 0.255
Vδ2 (% of γδ T cells)	0.482, 0.007	0.307, 0.106	0.531, 0.062	0.300, 0.242
Vδ2+NKG2D+ (% of lymphocyte)	0.373, 0.042	0.090, 0.641	0.314, 0.297	0.314, 0.219
Vδ1/Vδ2	−0.482, 0.007	−0.135, 0.485	−0.547, 0.053	−0.303, 0.237

CA125
Treg (% of lymphocyte)	0.513, 0.005	0.449, 0.015	0.351, 0.239	0.580, 0.015
Tfh1/Tfh2	0.340, 0.001	0.543, 0.002	0.281, 0.353	0.349, 0.169
Vδ1/Vδ2	0.431, 0.017	0.022, 0.909	0.055, 0.859	0.608, 0.010
Vδ2+NKG2D+ (% of lymphocyte)	−0.363, 0.049	−0.294, 0.122	−0.198, 0.517	−0.423, 0.091
Vδ2+PD1+ (% of lymphocyte)	−0.381, 0.038	−0.310, 0.102	−0.071, 0.817	−0.586, 0.013

Data were presented as correlation coefficients (r) and values. ¹The characteristics of the biggest myoma. ²Z and values of Mann–whitney U test. ³Adjusted for age. Hb, hemoglobin; RBC, red blood cells.