Pregnancy Hypertension and a Commonly Inherited IGF1R Variant (rs2016347) Reduce Breast Cancer Risk by Enhancing Mammary Gland Involution

Table 2

Results of adjusted negative binomial model with interaction terms.

	Coefficient	Standard error	Z Value	value	CR (95% CI)
HDP	0.208	0.345	0.604	0.546	1.231 (0.627, 2.419)
T alleles = 1	−0.027	0.268	−0.102	0.918	0.973 (0.575, 1.645)
T alleles = 2	0.099	0.307	0.322	0.747	1.104 (0.605, 2.016)
HDP × T alleles = 1	−0.310	0.417	−0.743	0.457	0.734 (0.324, 1.661)
HDP × T alleles = 2	−0.740	0.482	−1.536	0.124	0.477 (0.185, 1.227)

HDP compares HDP-postive women to HDP-negative women. T alleles are treated as a factor variable. The reference for T alleles is no T alleles (T alleles = 0). These results are adjusted for family history, age at biopsy, parity, age at menarche, age at first birth, and BMI. Full model covariates can be found in the supplemental material (Table S2).