Overexpression of Kynurenine 3-Monooxygenase Correlates with Cancer Malignancy and Predicts Poor Prognosis in Canine Mammary Gland Tumors

Figure 6

Downregulated KMO activities with KMO inhibitor or siRNA inhibited cell proliferation in CMT cells. (a) KMO expression in CMT-1 and MPG cells. (b) Cells treated with Ro 61-8048 for 24, 48, and 72 hrs were found to exhibit significantly suppressed cell proliferation of CMT-1 and MPG cells. (c) Knockdown of KMO with siRNA reduced cell proliferation in comparison to cells with control siRNA treatment. Columns, mean; bars, SD (n = 3). P < 0.01.

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