Research Article
Overexpression of Kynurenine 3-Monooxygenase Correlates with Cancer Malignancy and Predicts Poor Prognosis in Canine Mammary Gland Tumors
Table 3
Characteristics of the patients correlated with expression of KMO protein.
| | Characteristics | | KMO | | P value | | | Negative 0-3 | Weak 4-6 | Strong 7-9 | |
| | All patients | 6/ 86 (7%) | 41/86 (48%) | 39/86 (45%) | | | Age | | | | | | <9 years | 4/6 (67%) | 12/41 (29%) | 6/39 (15%) | | | ≥ 9 years | 2/6 (33%) | 29/41 (71%) | 33/39 (85%) | 0.271 | | Tumor size | | | | | | ≤ 5 cm maximum diameter | 4/6 (67%) | 31/41 (76%) | 25/39 (64%) | | | > 5 cm maximum diameter | 2/6 (33%) | 10/41 (24%) | 14/39 (36%) | 0.028 | | Ovariohysterectomy status | | | | | | No | 5/6 (100%) | 37/41 (90%) | 18/39 (47%) | 0.031 | | Yes | 1/6 (0%) | 4/41 (10%) | 21/39 (53%) | | | Malignancy | | | | | | Benign | 6/6 (100%) | 31/41 (76%) | 12/39 (31%) | | | Malignant | 0/6 (0%) | 10/41 (24%) | 27/39 (69%) | 0.0004 | | Tumor stage (N=37) | | | | | | I, II and III | --- | 3/10 (30%) | 11/27 (41%) | | | IV and V | --- | 7/10 (70%) | 16/27 (59%) | 0.046 | | Lymph node metastasis | | | | | | No | --- | 7/10 (70%) | 16/27 (59%) | 0.208 | | Yes | --- | 3/10 (30%) | 11/27 (41%) | | | Distant metastasis | | | | | | No | --- | 8/10 (80%) | 24/27 (89%) | 0.951 | | Yes | --- | 2/10 (20%) | 3/27 (11%) | | | Recurrence | | | | | | No | 6/6 (100%) | 19/41 (46%) | 9/27 (33%) | | | Yes | 0/6 (0%) | 22/41 (54%) | 18/27 (67%) | 0.025 |
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