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| Genitourinary complications | Initial therapy | Auxiliary treatment | BCG adjustment |
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| Cystitis (irritative voiding symptoms > 48 hours or intolerable) | Spasmolytics, anticholinergics or nonsteroidal anti-inflammatory drugs | Antibiotics administration If bacterial cystitis is diagnosed | Withheld until symptom relieves and antibiotic therapy ends |
| Bladder contracture | Bladder hydrodistension | Systemic steroids;
Exceptionally surgery (bladder augmentation or cystectomy) | Discontinue for decreased bladder capacity |
| Bladder ulceration | 300 mg isoniazid and 600 mg rifampin daily for 6 months | None | Withheld until resolution of the bladder lesion and BCG negative urine |
| Granulomatous balanitis | Various combinations of isoniazid, ethambutol or rifampin for 6 to 12 months | None | Withheld until the lesion resolves |
| Tuberculous epididymo-orchitis | 300 mg isoniazid and 600 mg rifampin daily for 3 to 6 months | For isoniazid resistance, fluoroquinolones or an anti-TB aminoglycoside;
For lesion refractory to anti-TB therapy, scrotal exploration and epididymo-orchiectomy | No further BCG |
| Symptomatic prostatitis | 300 mg isoniazid and 600 mg rifampin daily for 3 to 6 months | Antibiotics (fluoroquinolones) as necessary;
Surgical drainage for abscess;
Biopsy if no improvement on medication | No further BCG |
| Ureteral obstruction | 300 mg isoniazid and 600 mg rifampin daily for 3 to 6 months | A temporary drainage (ureteral stenting or percutaneous nephrostomy) for hydronephrosis despite conservative therapy | Withheld when onset hydronephrosis; May resume after resolution |
| Kidney infections | 300 mg isoniazid, 600 mg rifampin and 1200 mg ethambutol daily for 6 months | Biopsy if no response to medical treatment | No further BCG |
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