|
| Author | Year | Agents | Origin | Cell lines | Target molecules | Tools | Outcomes | Reference |
|
| Yashiro M et al. | 2003 | Tranilast | Chemical | OCUM-2D | Matrix metalloproteinse-2
Transforming growth factor-beta 1 | Invasion assay | Invasiveness | [51] |
|
| Onoyama M et al. | 2013 | Nilotinib with
Everolimus | Chemical | TMK-1
MKN-1
KKLS | PDGF-R tyrosine kinase
and
Mammalian target of rapamycin | Xenograft | Tumor growth
Angiogenesis
Metastasis
Stromal reaction | [52] |
|
| Hara M et al. | 2016 | Itraconazole | Chemical | HT-29 (colon)
MKN-28
MKN-45 | Mitogen-activated protein kinase
Protein S6 | Flow cytometry
Angiogenesis assay
Xenograft | Angiogenesis
Tumor growth | [53] |
|
| Izumi D et al. | 2016 | AF-310-NA
AMD3100
PF-573,228 | Antibody
Chemical
Chemical | AGS
KATOIII | CXCL12
CXCR4
Focal adhesion kinase | Real-time imaging
Invasion assay | Migration
Invasiveness | [42] |
|
| Jin H et al. | 2017 | 7rh | Chemical | MKN-45
MKN-74 | Discoidin domain receptor 1 | Spheroid culture
Xenograft | Tumorigenesis | [54] |
|
| Pang T et al. | 2017 | Fiber-modified hexon-chimeric oncolytic adenovirus | Adenovirus | MKN-45 | Fibroblast activation protein
(for CAF-specific infection) | Cell viability assay
Xenograft | Tumor growth | [55] |
|
| Wang Z et al. | 2017 | Triptonide | Natural products (Tripterygium wilfordii) | BGC-823 | microRNA-149 ↑
microRNA-301a ↓ | Colony formation assay
Wound healing assay
Invasion assay | Tumorigenesis
Migration
Invasiveness | [56] |
|
| Wang ZF et al. | 2017 | Astragaloside IV | Natural products (Astragali Radix) | BGC-823 | microRNA-214 ↑
microRNA-301a ↓ | Proliferation assay
Wound healing assay
Invasion assay | Proliferation
Migration
Invasiveness | [57] |
|
| Ding X et al. | 2018 | LY294002
U0126 | Chemical | | AKT
ERK 1/2 | Angiogenesis assay | Angiogenesis | [58] |
|
| Dong R et al. | 2018 | Polyphyllin I | Chemical | MKN-45 | Fibroblast activation protein alpha
Hepatocyte growth factor | Proliferation assay
Xenograft | Proliferation
Tumor growth | [59] |
|
| Karakasheva TA et al. | 2018 | Tocilizumab | Antibody | ESCC
EAC | IL-6 receptor alpha | 3D culture
3D organotypic culture
Xenograft | Tumorigenesis | [60] |
|
| Wang ZF et al. | 2018 | Paeoniflorin | Natural products
(Radix Paeoniae Rubra) | AGS | microRNA-149
Interleukin 6 | Wound healing assay
Invasion assay | Migration
Invasiveness | [61] |
|
| Chen G et al. | 2019 | Metformin | Chemical | | Calmodulin-like protein 3 | Proliferation assay | Tumor promotion | [62] |
|
