A Perspective Review on the Role of Nanomedicine in the Modulation of TNF-TNFR2 Axis in Breast Cancer Immunotherapy

Table 2

The biological subtypes of breast cancer.

Subtypes	Estrogen receptor; (ER)	Human epidermal growth factor receptor-2 (HER2)	Ki-67; protein	Progesterone; receptor; (PR)	Comment
Luminal A; Luminal B	Positive; Positive	Negative; Positive or Negative	Low; High	Positive or Negative; Positive or Negative	In comparing luminal A and B, luminal A is reported to be growing slower than luminal B, which means best prognosis in luminal A cancer; Ki-67 helps in monitoring how fast tumours grow.
Triple-negative (basal-like)	Negative	Negative	-	Negative	It is defined as basal-like breast cancer and is more common among young women especially with BRCA1 gene mutations.
HER2-enriched	Negative	Positive	-	Negative	This cancer is growing faster than luminal cancers but with worse prognosis.
Normal-like	Positive	Negative	Low	Positive or Negative	Although ‘normal-like’ is similar to luminal A, its prognosis is worse than luminal A.