Cytoplasmic HAX1 Is an Independent Risk Factor for Breast Cancer Metastasis
Figure 3
HAX1 overexpression is higher in patients with breast cancer relapse and has prognostic impact on ER+ subset of patients. (a) RFS analysis for total number of patients and subsets with different ER status (left: ER+; right: ER-). Patients were split into groups with high and low HAX1 expression (based on microarray data, split by median). Kaplan-Meier estimates were generated in KM Plotter online tool for all data available for 2017 (merged datasets). Probability of cancer relapse is plotted against time. (b) Forest plots estimating prognostic impact of HAX1 expression in ER+ (n = 2,822) and ER- (n = 1,072) subsets of patients with metastatic relapse information (bcGenExMiner). Values in columns represent summarized univariate Cox scores (p-values, hazard ratios) for each cohort fulfilling the chosen criteria and for pooled cohorts. MR: metastatic relapse.