Cytoplasmic HAX1 Is an Independent Risk Factor for Breast Cancer Metastasis
Figure 5
HAX1 protein level in primary tumor is a risk factor for breast cancer progression. (a-c) Receiver operating characteristic analysis for (a) cytoplasmic, (b) total, and (c) nuclear HAX1 protein levels was performed to define the best cutoff values for subsequent survival analysis. Area under curve (AUC) with 95% CI and p-values for each ROC curve are shown. (d-f) Kaplan-Meier survival estimates for distant recurrence-free survival (DRFS) and overall survival (OS) in breast cancer patients according to proposed cutoff values of (d) cytoplasmic HAX1 protein levels ≤1.02 (n=28) versus >1.02 (n=18), (e) total HAX1 protein levels ≤1.49 (n=18) versus >1.49 (n=28), and (f) nuclear HAX1 protein levels ≤1.05 (n=31) versus >1.05 (n=15). The log-rank test was used to evaluate the equality of survivor function for groups with lower and higher HAX1 expression and p-values <0.05 were considered significant.