Cytoplasmic HAX1 Is an Independent Risk Factor for Breast Cancer Metastasis

Table 1

Multivariate Cox regression analysis of HAX1 levels in human breast cancers.

Evaluation of HAX1 levels in the cell nuclei
Variable name	OS (23/46)^1	DRFS (28/46)^1
	HR (95% CI), p	HR (95% CI), p
HAX1 (≤1.05 vs. >1.05)	NS	NS
Histological grade (2 vs. 1)	6.06E+8 (2.26E+8-1.63E+9), <0.001	NS
Clinical stage (III vs. I)	3.171 (1.017-9.884), 0.047	NS
Evaluation of HAX1 levels in the cytoplasm
Variable name	OS (23/46)	DRFS (28/46)
	HR (95% CI), p	HR (95% CI), p
HAX1 (≤1.02 vs. >1.02)	NS	2.832 (1.207-6.644), 0.017
Histological grade (2 vs. 1)	4.86E+8 (1.74E+8-1.36E+9), <0.001	NS
Evaluation of HAX1 levels in both of the nuclei and the cytoplasm
Variable name	OS (23/46)	DRFS (28/46)
	HR (95% CI), p	HR (95% CI), p
HAX1 (≤2.06 vs. >2.06)	NS	4.249 (1.404-12.86), 0.010
Histological grade (2 vs. 1)	3.44E+8 (1.17E+8-1.01E+9), <0.001	NS

The multivariate analysis of prognosis was carried out using the Cox proportional hazards model. Values before and after a slash (/) stand for the number of complete observations versus all observations, respectively. Only the results with p-values <0.05 are shown and those with p-values <0.05 for HAX1 expression are highlighted in italic type. HR and CI stand for the hazard ratio and confidence interval, respectively. OS: overall survival; DRFS: distant recurrence-free survival; NS: a nonsignificant result (p ≥0.05).