Overexpression of DCLK1-AL Increases Tumor Cell Invasion, Drug Resistance, and KRAS Activation and Can Be Targeted to Inhibit Tumorigenesis in Pancreatic Cancer

Figure 2

High DCLK1 expression in normal adjacent tissue of PDAC correlates with poor survival. (a) The intensity of DCLK1 expression in PDAC normal adjacent tissue (NAT) was scored based on staining using anti-DCLK1 antibody on a commercially available tissue microarray. Kaplan-Meier analysis of the DCLK1 staining scores demonstrated that patients with high levels of DCLK1 in the NAT had significantly shorter survival time compared to patients with low levels of DCLK1 in the NAT. (b) Representative images of low and high DCLK1 staining in NAT. (c) Multivariate Cox regression analysis of patients included in the TMA.

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