Role of Four ABC Transporter Genes in Pharmacogenetic Susceptibility to Breast Cancer in Jordanian Patients

Table 3

Genetic association analysis for the ABCC1, ABCC2, ABCB1, and ABCG2 SNPs using different genetic models.

Gene	SNP ID	Category Test	Odds Ratio	95% CI	Chi square
ABCC1	rs35626	Het (GT) vs. Common Hz (GG)	0.84	0.56-1.27	0.65
		Rare Hz (TT) vs. Het (GT)	0.73	0.42-1.25	1.31
		Rare Hz (TT) vs. Common Hz (GG)	0.61	0.36-1.06	3.04
	rs35628	Het (AG) vs. Common Hz (AA)	0.87	0.52-1.44	0.29
		Rare Hz (GG) vs. Het (AG)	1.4	0.35-5.63	0.22
		Rare Hz (GG) vs. Common Hz (AA)	1.22	0.32-4.6	0.08
	rs4148351	Het (CT) vs. Common Hz (CC)	0.6	0.39-0.93	5.33
		Rare Hz (TT) vs. Het (AG)	1.58	0.6-4.19	0.88
		Rare Hz (TT) vs. Common Hz (CC)	0.96	0.38-2.43	0.01
ABCC2	rs2273697	Het (GA) vs. Common Hz (GG)	1.55	0.71-3.42	1.21
		Rare Hz (AA) vs. Het (GA)	0.8	0.54-1.2	1.14
		Rare Hz (AA) vs. Common Hz (GG)	1.25	0.58-2.68	0.32
	rs3740065	Het (GA) vs. Common Hz (AA)	1.35	0.9-2.03	2.08
		Rare Hz (GG) vs. Het (GA)	0.63	0.27-1.48	1.16
		Rare Hz (GG) vs. Common Hz (AA)	0.85	0.37-1.93	0.16
	rs717620	Het (CT) vs. Common Hz (CC)	0.97	0.61-1.53	0.02
		Rare Hz (TT) vs. Het (CT)	0.8	0.2-3.17	0.1
		Rare Hz (TT) vs. Common Hz (CC)	0.78	0.2-2.94	0.14
ABCB1	rs1045642	Het (CT) vs. Common Hz (CC)	0.72	0.48-1.1	2.32
		Rare Hz (TT) vs. Het (CT)	0.85	0.5-1.43	0.39
		Rare Hz (TT) vs. Common Hz (CC)	0.61	0.37-1.03	3.46
	rs1128503	Het (GA) vs. Common Hz (AA)	1.25	0.74-2.1	0.68
		Rare Hz (GG) vs. Het (GA)	1.42	0.93-2.16	2.65
		Rare Hz (GG) vs. Common Hz (AA)	1.77	1.04-2.99	4.52

For significant association χ2 should be >3.84 with P<0.025.
CI indicates confidence interval.