SOX9 Stem-Cell Factor: Clinical and Functional Relevance in Cancer

Figure 1

MiniSOX9 has an oncogenic behavior in CRC. (a) In normal conditions canonical Wnt/β-catenin pathway triggers SOX9 expression resulting in regulation of differentiation and homeostasis in intestinal epithelium. (b) Truncated version of SOX9, MiniSOX9, accumulates in the nucleus to inhibit SOX9 DNA-binding-dependent transcriptional activity and PKC-alpha expression.

(a)

(b)