SOX9 Stem-Cell Factor: Clinical and Functional Relevance in Cancer

Table 1

SOX9 expression and functions in human cancers.

Type of cancer	Status of SOX9	Sox9 participation	References
Hepatocellular carcinoma	overexpression	Related whit poor prognosis; Related with poor disease free survival; Related with poor overall survival	[22, 23]
Breast cancer	overexpression	Promotes proliferation, tumorigenesis and metastasis Related with poor overall survival	[24]
Bladder cancer	overexpression	Promotes tumorigenesis; Related with poor overall survival	[25]
Gastric cancer	overexpression	Promotes chemoresistance; Related with poor disease free survival	[26]
Prostate cancer	overexpression	Promotes cell proliferation and apoptosis resistance; Related with high clinical stage; Related with poor relapse free survival; Related with poor overall survival	[27]
Prostate cancer	downregulation	Promotes metastasis; Related with advanced clinical stage; Related with EGR-positive tumors	[28]
Ovarian cancer	overexpression	Its coexpression with HIF-2α induces the expression of TUBB3 which is related with poor overall survival	[29]
Pancreatic cancer	overexpression	Promotes chemoresistance	[30]
colorectal cancer	overexpression	Promotes cell proliferation, senescence inhibition and chemoresistance	[31–33]