The Role of Nonerythroid Spectrin II in Cancer

Table 1

SPTAN1 in various cancer types.

Tumor Type	Changes in SPTAN1	References
Colorectal cancer (CRC)	SPTAN1 upregulation	[28]
	SPTAN1 downregulation in MLH1-deficient CRC	[29]
	SPTAN1 upregulation in sporadic CRC, SPTAN1 downregulation in MLH1-deficient CRC	[30]
Gastric cancer	SPTAN1 upregulation	[28, 31, 32]
Lung cancer	SPTAN1 upregulation	[33]
	SPTAN1 mutations and downregulation	[34]
Breast cancer	SPTAN1 upregulation (cytoplasmic)	[28, 35, 36]
Bladder cancer	Recurrence-associated SPTAN1 alterations	[37]
Prostate cancer	SPTAN1 downregulation in lung metastasis, SPTAN1 as progression gene	[38]
Cutaneous tumors	SPTAN1 upregulation (cytoplasmic)	[39]
Soft-tissue tumors	SPTAN1 upregulation in more aggressive mesenchymal tumors	[40]
Ovarian cancer	SPTAN1 upregulation after chemotherapy	[41]
Atypical chronic myeloid leukaemia (aCML)	Novel CSF3R-SPTAN1 fusion gene	[42]
Non-Hodgkin lymphoma	SPTAN1 as target protein in postchemotherapy	[43]
Non-Hodgkin lymphoma, acute lymphoblastic leukaemia (ALL)	SPTAN1 upregulation after chemotherapy in nuclear area	[44]