Not Only Mutations Matter: Molecular Picture of Acute Myeloid Leukemia Emerging from Transcriptome Studies

Figure 2

The milestones in genomic and transcriptomic research of acute myeloid leukemia. A symbolic mRNA molecule serves as a timeline on which the most important papers and events are marked, starting from the first FAB classification of AML in 1976 [9] and its revised version published in 1985 [10]. The microscopic images of M1-M7 FAB AML types come from the private collection of Prof. John M. Bennett and were used thanks to the courtesy of the Professor. The original pictures from the following publications were used with the permission of the authors and magazine publishers: Schena et al., PNAS 1996 [47] (Copyright 1996 National Academy of Sciences); Golub et al., Science 1999 [20] (reprinted with permission of AAAS); Lu et al., Nature 2005 [51] (reprinted by permission from Springer Nature, Nature, Copyright 2005); Falini et al., NEJM 2005 [52] (Copyright 2005 Massachusetts Medical Society, reprinted with permission from Massachusetts Medical Society); Haferlach et al., Blood 2005 [53] (reprinted by permission from American Society of Hematology, Copyright 2005); Mi et al. PNAS 2007 [54] (Copyright 2007 National Academy of Sciences); TCGA paper from NEJM 2013 [23] (Copyright 2013 Massachusetts Medical Society, reprinted with permission from Massachusetts Medical Society); Tyner et al. Nature 2018 [25] (reprinted by permission from Springer Nature, Nature, Copyright 2018); Hoadley et al., Cell 2018 [55] (reprinted by permission from Elsevier, Cell, Copyright 2018). Two Nature journal covers were reprinted by permission from Springer Nature, Nature, Copyright 2001 and 2008. Two Science journal covers, from 1999 and 2001, were reprinted with permission of AAAS. WHO publication cover images were reproduced with permission from Jaffe, E.S., Harris. N.L., Stein, H., Vardiman, J.W., Eds. WHO Classification of Tumours, Pathology and Genetics of Tumours of Haematopoietic and Lymphoid Tissues, IARC, Lyon, 2001 [11]; Swerdlow, SH, Campo, E, Harris, NL, Jaffe, ES, Pileri, SA, Stein, H, Thiele, J, Vardiman, JW. World Health Organization Classification of Tumours of Haematopoietic and Lymphoid Tissues. IARC, Lyon, 2008; Swerdlow, SH, Campo, E, Harris, NL, Jaffe, ES, Pileri, SA, Stein, H, Thiele, J, Arber DA, Hasserjian RP, Le Beau MM, Orazi A, Siebert R. World Health Organization Classification of Tumours of Haematopoietic and Lymphoid Tissues, revised 4th edition. IARC, Lyon, 2017. The photograph of Francis Collins and Craig Venter, made by Chuck Kennedy in 2000 (krtphotos001229) was used with the license of Newscom (https://www.newscom.com). Vitruvian man image was downloaded from Wikimedia Commons under a free license (https://commons.wikimedia.org/wiki/File:Vitruvian_man.jpg). Graphics representing the Human Genome Project (HGP) were used thanks to the courtesy of National Human Genome Research Institute ((NHGRI, https://www.genome.gov). The TCGA logo was used with the permission of National Cancer Institute (NCI, https://www.cancer.gov).