Inflammatory Biomarkers as Predictors of Response to Immunotherapy in Urological Tumors

Figure 2

Factors influencing immune response and possibly related to resistance to immunotherapy. TMB: tumor mutational burden; PD-L1: programmed death-ligand 1; LAG-3: lymphocyte-activation gene-3; TIM-3: T-cell immunoglobulin and mucin domain 3; TILs: tumor-infiltrating lymphocytes; IDO: indoleamine-2,3-dioxygenase; TGF-β: transforming growth factor-β; CXCR: CXC chemokine receptors; CXCL: CXC chemokine receptors ligands; NLR: neutrophil-to-lymphocyte ratio; SII: systemic immune-inflammation index.