IL-2 Induces Transient Arrest in the G1 Phase to Protect Cervical Cancer Cells from Entering Apoptosis

<div>IL-2 protects G1-arrested cervical cancer cells from entering apoptosis. Cells were incubated in the presence or absence of 100 IU/ml of IL-2 for 48 hours. Then, 5 <i>μ</i>g/ml of cisplatin was added to the cell cultures, and the mixtures were incubated for 24 and 48 hours. Apoptosis was evaluated using the PE Annexin-V kit apoptosis detection kit. The percentage of apoptotic cells was evaluated by flow cytometry. Percentage of cell death in HeLa cells (a) and INBL cells (b) is shown. Statistical analysis was performed with a Student’s <i>t-</i>test of paired, nonparametric data. 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Journal of Oncology

fig8

Figure 8

Figure 8: IL-2 Induces Transient Arrest in the G1 Phase to Protect Cervical Cancer Cells from Entering Apoptosis 