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Journal of Oncology
Volume 2019, Article ID 7479518, 11 pages
https://doi.org/10.1155/2019/7479518
Review Article

The Protective Effect of Dietary Phytosterols on Cancer Risk: A Systematic Meta-Analysis

1Department of Oncology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China
2Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China
3Department of Plastic and Burns Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China
4Department of Cardiovascular Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China
5Department of Thoracic Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China
6Department of Oncology, Sir Run Run Hospital, Nanjing Medical University, Nanjing, China

Correspondence should be addressed to Wei Wang; moc.361@rotcod-iewgnaw and Lingjun Zhu; nc.ude.umjn@nujgniluhz

Received 28 January 2019; Revised 18 May 2019; Accepted 30 May 2019; Published 23 June 2019

Academic Editor: Francesca De Felice

Copyright © 2019 Lu Jiang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. L. A. Torre, F. Bray, R. L. Siegel, J. Ferlay, and J. Lortet-Tieulent, “Global cancer statistics, 2012,” CA: A Cancer Journal for Clinicians, vol. 65, no. 2, pp. 87–108, 2015. View at Publisher · View at Google Scholar
  2. M. J. Thun, J. O. DeLancey, M. M. Center, A. Jemal, and E. M. Ward, “The global burden of cancer: priorities for prevention,” Carcinogenesis, vol. 31, no. 1, pp. 100–110, 2009. View at Publisher · View at Google Scholar · View at Scopus
  3. B. Pagliaro, C. Santolamazza, F. Simonelli, and S. Rubattu, “Phytochemical compounds and protection from cardiovascular diseases: a state of the art,” BioMed Research International, vol. 2015, Article ID 918069, 17 pages, 2015. View at Publisher · View at Google Scholar
  4. Y.-J. Zhang, R.-Y. Gan, S. Li et al., “Antioxidant phytochemicals for the prevention and treatment of chronic diseases,” Molecules, vol. 20, no. 12, pp. 21138–21156, 2015. View at Publisher · View at Google Scholar · View at Scopus
  5. M. J. Howes and M. S. Simmonds, “The role of phytochemicals as micronutrients in health and disease,” Current Opinion in Clinical Nutrition & Metabolic Care, vol. 17, no. 6, pp. 558–566, 2014. View at Publisher · View at Google Scholar
  6. S. G. J. van Breda and T. M. de Kok, “Smart combinations of bioactive compounds in fruits and vegetables may guide new strategies for personalized prevention of chronic diseases,” Molecular Nutrition & Food Research, vol. 62, no. 1, 2018. View at Publisher · View at Google Scholar
  7. V. P. Nepal, O. Mgbere, D. Banerjee, and R. Arafat, “Determinants of fruits and vegetables consumption among persons with doctor-diagnosed chronic diseases,” Journal of Primary Care & Community Health, vol. 3, no. 2, pp. 132–141, 2012. View at Publisher · View at Google Scholar
  8. P. G. Bradford and A. B. Awad, “Phytosterols as anticancer compounds,” Molecular Nutrition & Food Research, vol. 51, no. 2, pp. 161–170, 2007. View at Publisher · View at Google Scholar · View at Scopus
  9. A. V. Rao and S. A. Janezic, “The role of dietary phytosterols in colon carcinogenesis,” Nutrition and Cancer, vol. 18, no. 1, pp. 43–52, 1992. View at Publisher · View at Google Scholar · View at Scopus
  10. G. P. Zaloga, “Phytosterols, lipid administration, and liver disease during parenteral nutrition,” Journal of Parenteral and Enteral Nutrition, vol. 39, pp. 39S–60S, 2015. View at Publisher · View at Google Scholar
  11. S. B. Racette, X. Lin, L. Ma, and Jr Ostlund, “Natural dietary phytosterols,” Journal of AOAC International, vol. 98, no. 3, pp. 679–684, 2015. View at Publisher · View at Google Scholar
  12. T. Bacchetti, S. Masciangelo, V. Bicchiega, E. Bertoli, and G. Ferretti, “Phytosterols, phytostanols and their esters: from natural to functional foods,” Mediterranean Journal of Nutrition and Metabolism, vol. 4, no. 3, pp. 165–172, 2011. View at Publisher · View at Google Scholar · View at Scopus
  13. P. J. Jones and S. S. AbuMweis, “Phytosterols as functional food ingredients: linkages to cardiovascular disease and cancer,” Current Opinion in Clinical Nutrition and Metabolic, vol. 12, no. 2, pp. 147–151, 2009. View at Publisher · View at Google Scholar
  14. E. Ros, “Health benefits of nut consumption,” Nutrients, vol. 2, no. 7, pp. 652–682, 2010. View at Publisher · View at Google Scholar
  15. L. Calpe-Berdiel, J. C. Escolà-Gil, and F. Blanco-Vaca, “New insights into the molecular actions of plant sterols and stanols in cholesterol metabolism,” Atherosclerosis, vol. 203, no. 1, pp. 18–31, 2009. View at Publisher · View at Google Scholar · View at Scopus
  16. E. Misawa, M. Tanaka, K. Nomaguchi et al., “Oral ingestion of Aloe vera phytosterols alters hepatic gene expression profiles and ameliorates obesity-associated metabolic disorders in Zucker diabetic fatty rats,” Journal of Agricultural and Food Chemistry, vol. 60, no. 11, pp. 2799–2806, 2012. View at Publisher · View at Google Scholar · View at Scopus
  17. P. Suttiarporn, W. Chumpolsri, S. Mahatheeranont, S. Luangkamin, S. Teepsawang, and V. Leardkamolkarn, “Structures of phytosterols and triterpenoids with potential anti-cancer activity in bran of black non-glutinous rice,” Nutrients, vol. 7, no. 3, pp. 1672–1687, 2015. View at Publisher · View at Google Scholar
  18. E. A. Trautwein and I. Demonty, “Phytosterols: natural compounds with established and emerging health benefits,” OCL - Oilseeds and fats, Crops and Lipids, vol. 14, no. 5, pp. 259–266, 2007. View at Publisher · View at Google Scholar · View at Scopus
  19. V. R. Ramprasath and A. B. Awad, “Role of phytosterols in cancer prevention and treatment,” Journal of AOAC International, vol. 98, no. 3, pp. 735–738, 2015. View at Publisher · View at Google Scholar
  20. A. A. Baskar, K. S. Al Numair, M. Gabriel Paulraj, M. A. Alsaif, M. A. Muamar, and S. Ignacimuthu, “β-sitosterol prevents lipid peroxidation and improves antioxidant status and histoarchitecture in rats with 1,2-dimethylhydrazine-induced colon cancer,” Journal of Medicinal Food, vol. 15, no. 4, pp. 335–343, 2012. View at Publisher · View at Google Scholar · View at Scopus
  21. F. Guo and C.-J. Xu, “Progress on the study of mechanism of the direct action of TCM bioactive components on ovarian cancer,” Chinese Journal of Integrated Traditional and Western Medicine, vol. 25, no. 12, pp. 1140–1144, 2005. View at Google Scholar · View at Scopus
  22. Y. H. Choi, K. R. Kong, Y. A. Kim et al., “Induction of Bax and activation of caspases during β-sitosterol-mediated apoptosis in human colon cancer cells,” International Journal of Oncology, vol. 23, pp. 1657–1662, 2003. View at Publisher · View at Google Scholar
  23. A. B. Awad, A. T. Burr, and C. S. Fink, “Effect of resveratrol and β-sitosterol in combination on reactive oxygen species and prostaglandin release by PC-3 cells,” Prostaglandins, Leukotrienes and Essential Fatty Acids, vol. 72, no. 3, pp. 219–226, 2005. View at Publisher · View at Google Scholar
  24. P. J. D. Bouic, S. Etsebeth, R. W. Liebenberg, C. F. Albrecht, K. Pegel, and P. P. Van Jaarsveld, “Beta-sitosterol and beta-sitosterol glucoside stimulate human peripheral blood lymphocyte proliferation: implications for their use as an immunomodulatory vitamin combination,” International Journal of Immunopharmacology, vol. 18, no. 12, pp. 693–700, 1996. View at Publisher · View at Google Scholar · View at Scopus
  25. P. J. D. Bouic, “The role of phytosterols and phytosterolins in immune modulation: a review of the past 10 years,” Current Opinion in Clinical Nutrition & Metabolic Care, vol. 4, no. 6, pp. 471–475, 2001. View at Publisher · View at Google Scholar · View at Scopus
  26. M. Covas, “Effect of olive oil minor components on oxidative stress and arachidonic acid mobilization and metabolism by macrophages RAW 264.7,” Clínica e Investigación en Arteriosclerosis, vol. 16, no. 6, pp. 283–285, 2004. View at Publisher · View at Google Scholar
  27. A. B. Awad, J. Toczek, and C. S. Fink, “Phytosterols decrease prostaglandin release in cultured P388D1/MAB macrophages,” Prostaglandins, Leukotrienes and Essential Fatty Acids, vol. 70, no. 6, pp. 511–520, 2004. View at Publisher · View at Google Scholar
  28. J. Luo, L. Shen, and D. Zheng, “Association between vitamin C intake and lung cancer: a dose-response meta-analysis,” Scientific Reports, vol. 4, no. 1, article 6161, 2015. View at Publisher · View at Google Scholar
  29. F. Chen, Q. Li, Y. Yu, W. Yang, F. Shi, and Y. Qu, “Association of vitamin C, vitamin D, vitamin E and risk of bladder cancer: a dose-response meta-analysis,” Scientific Reports, vol. 5, no. 1, article 9599, 2015. View at Publisher · View at Google Scholar
  30. X. Y. Bai, X. Qu, X. Jiang et al., “Association between dietary vitamin C intake and risk of prostate cancer: a meta-analysis involving 103,658 subjects,” Journal of Cancer, vol. 6, no. 9, pp. 913–921, 2015. View at Publisher · View at Google Scholar
  31. P. Chen, C. Li, X. Li, J. Li, R. Chu, and H. Wang, “Higher dietary folate intake reduces the breast cancer risk: a systematic review and meta-analysis,” British Journal of Cancer, vol. 110, no. 9, pp. 2327–2338, 2014. View at Publisher · View at Google Scholar
  32. M. Tio, J. Andrici, M. R. Cox, and G. D. Eslick, “Folate intake and the risk of prostate cancer: a systematic review and meta-analysis,” Prostate Cancer and Prostatic Diseases, vol. 17, no. 3, pp. 213–219, 2014. View at Publisher · View at Google Scholar
  33. H. He and B. Shui, “Folate intake and risk of bladder cancer: a meta-analysis of epidemiological studies,” International Journal of Food Sciences and Nutrition, vol. 65, no. 3, pp. 286–292, 2014. View at Publisher · View at Google Scholar
  34. Y. Wang, R. Cui, Y. Xiao, J. Fang, Q. Xu, and B. O. Williams, “Effect of carotene and lycopene on the risk of prostate cancer: a systematic review and dose-response meta-analysis of observational studies,” PLoS ONE, vol. 10, no. 9, Article ID e0137427, 2015. View at Publisher · View at Google Scholar
  35. N. Yu, X. Su, Z. Wang, B. Dai, and J. Kang, “Association of dietary vitamin A and β-carotene intake with the risk of lung cancer: a meta-analysis of 19 publications,” Nutrients, vol. 7, no. 11, pp. 9309–9324, 2015. View at Publisher · View at Google Scholar · View at Scopus
  36. X.-X. Ge, M.-Y. Xing, L.-F. Yu, and P. Shen, “Carotenoid intake and esophageal cancer risk: a meta-analysis,” Asian Pacific Journal of Cancer Prevention, vol. 14, no. 3, pp. 1911–1918, 2013. View at Publisher · View at Google Scholar · View at Scopus
  37. E. S. Al-Sheddi, M. M. Al-Oqail, A. S. El-Shaibany, and N. N. Farshori, “Phytochemicals and their anti-proliferative activity of Aloe perryi flowers extract against various human cancer cell lines,” in Planta Medica, vol. 81, 2015. View at Publisher · View at Google Scholar
  38. Y.-S. Kim, X.-F. Li, K.-H. Kang, B. Ryu, and S. K. Kim, “Stigmasterol isolated from marine microalgae Navicula incerta induces apoptosis in human hepatoma HepG2 cells,” BMB Reports, vol. 47, no. 8, pp. 433–438, 2014. View at Publisher · View at Google Scholar · View at Scopus
  39. A. B. Awad, C. S. Fink, H. Williams, and U. Kim, “In vitro and in vivo (SCID mice) effects of phytosterols on the growth and dissemination of human prostate cancer PC-3 cells,” European Journal of Cancer Prevention, vol. 10, no. 6, pp. 507–513, 2001. View at Publisher · View at Google Scholar · View at Scopus
  40. R. L. von Holtz, C. S. Fink, and A. B. Awad, “β-Sitosterol activates the sphingomyelin cycle and induces apoptosis in LNCaP human prostate cancer cells,” Nutrition and Cancer, vol. 32, no. 1, pp. 8–12, 1998. View at Publisher · View at Google Scholar · View at Scopus
  41. A. B. Awad, S. L. Barta, C. S. Fink, and P. G. Bradford, “β-Sitosterol enhances tamoxifen effectiveness on breast cancer cells by affecting ceramide metabolism,” Molecular Nutrition & Food Research, vol. 52, no. 4, pp. 419–426, 2008. View at Publisher · View at Google Scholar · View at Scopus
  42. A. B. Awad, H. Williams, and C. S. Fink, “Phytosterols reduce in vitro metastatic ability of MDA-MB-231 human breast cancer cells,” Nutrition and Cancer, vol. 40, no. 2, pp. 157–164, 2001. View at Publisher · View at Google Scholar · View at Scopus
  43. R. Sharmila and G. Sindhu, “Modulation of angiogenesis, proliferative response and apoptosis by β-sitosterol in rat model of renal carcinogenesis,” Indian Journal of Clinical Biochemistry, vol. 32, no. 2, pp. 142–152, 2017. View at Publisher · View at Google Scholar
  44. R. F. Raicht, B. I. Cohen, E. P. Fazzini, A. N. Sarwal, and M. Takahashi, “Protective effect of plant sterols against chemically induced colon tumors in rats,” Cancer Research, vol. 40, no. 2, pp. 403–405, 1980. View at Google Scholar · View at Scopus
  45. B. Rubis, A. Paszel, M. Kaczmarek, M. Rudzinska, H. Jelen, and M. Rybczynska, “Beneficial or harmful influence of phytosterols on human cells?” British Journal of Nutrition, vol. 100, no. 6, pp. 1183–1191, 2008. View at Publisher · View at Google Scholar
  46. S. A. Janezic and A. V. Rao, “Dose-dependent effects of dietary phytosterol on epithelial cell proliferation of the murine colon,” Food and Chemical Toxicology, vol. 30, no. 7, pp. 611–616, 1992. View at Publisher · View at Google Scholar
  47. A. B. Awad, M. D. Garcia, and C. S. Fink, “Effect of dietary phytosterols on rat tissue lipids,” Nutrition and Cancer, vol. 29, no. 3, pp. 212–216, 1997. View at Publisher · View at Google Scholar · View at Scopus
  48. A. B. Awad, A. C. Downie, and C. S. Fink, “Inhibition of growth and stimulation of apoptosis by beta-sitosterol treatment of MDA-MB-231 human breast cancer cells in culture,” International Journal of Molecular Medicine, vol. 5, no. 5, pp. 541–545, 2000. View at Google Scholar · View at Scopus
  49. M. B. Katan, S. M. Grundy, P. Jones, M. Law, T. Miettinen, and R. Paoletti, “Efficacy and safety of plant stanols and sterols in the management of blood cholesterol levels,” Mayo Clinic Proceedings, vol. 78, no. 8, pp. 965–978, 2003. View at Publisher · View at Google Scholar · View at Scopus
  50. X. Li, Q. Wu, M. Bu et al., “Ergosterol peroxide activates Foxo3-mediated cell death signaling by inhibiting AKT and c-Myc in human hepatocellular carcinoma cells,” Oncotarget, vol. 7, no. 23, pp. 33948–33959, 2016. View at Publisher · View at Google Scholar
  51. C. Park, D. Moon, C. Rhu et al., “β-sitosterol induces anti-proliferation and apoptosis in human leukemic U937 cells through activation of caspase-3 and induction of Bax/Bcl-2 ratio,” Biological & Pharmaceutical Bulletin, vol. 30, no. 7, pp. 1317–1323, 2007. View at Publisher · View at Google Scholar
  52. Y. Nishizuka, “Intracellular signaling by hydrolysis of phospholipids and activation of protein kinase C,” Science, vol. 258, no. 5082, pp. 607–614, 1992. View at Publisher · View at Google Scholar · View at Scopus
  53. Y. A. Hannun and C. M. Linardic, “Sphingolipid breakdown products: anti-proliferative and tumor-suppressor lipids,” BBA - Reviews on Biomembranes, vol. 1154, no. 3-4, pp. 223–236, 1993. View at Publisher · View at Google Scholar · View at Scopus
  54. H. U. Schweikert, U. W. Tunn, U.-F. Habenicht et al., “Effects of estrogen deprivation on human benign prostatic hyperplasia,” The Journal of Steroid Biochemistry and Molecular Biology, vol. 44, no. 4-6, pp. 573–576, 1993. View at Publisher · View at Google Scholar · View at Scopus
  55. G. Flores and M. Ruiz del Castillo, “Cancer-related constituents of strawberry jam as compared with fresh fruit,” Cancers, vol. 8, no. 1, article 16, 2016. View at Publisher · View at Google Scholar
  56. J. Huang, M. Xu, Y. Fang et al., “Association between phytosterol intake and colorectal cancer risk: a case–control study,” British Journal of Nutrition, vol. 117, no. 6, pp. 839–850, 2017. View at Publisher · View at Google Scholar
  57. K. Penugonda and B. L. Lindshield, “Fatty acid and phytosterol content of commercial saw palmetto supplements,” Nutrients, vol. 5, no. 9, pp. 3617–3633, 2013. View at Publisher · View at Google Scholar · View at Scopus
  58. W. H. Ling and P. J. H. Jones, “Dietary phytosterols: a review of metabolism, benefits and side effects,” Life Sciences, vol. 57, no. 3, pp. 195–206, 1995. View at Publisher · View at Google Scholar · View at Scopus
  59. A. Stang, “Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses,” European Journal of Epidemiology, vol. 25, no. 9, pp. 603–605, 2010. View at Publisher · View at Google Scholar · View at Scopus
  60. J. P. T. Higgins and S. G. Thompson, “Quantifying heterogeneity in a meta-analysis,” Statistics in Medicine, vol. 21, no. 11, pp. 1539–1558, 2002. View at Publisher · View at Google Scholar · View at Scopus
  61. N. Mantel and W. Haenszel, “Statistical aspects of the analysis of data from retrospective studies of disease,” Journal of the National Cancer Institute, vol. 22, no. 4, pp. 719–748, 1959. View at Publisher · View at Google Scholar
  62. J. P. T. Higgins, S. G. Thompson, J. J. Deeks, and D. G. Altman, “Measuring inconsistency in meta-analyses,” British Medical Journal, vol. 327, no. 7414, pp. 557–560, 2003. View at Publisher · View at Google Scholar · View at Scopus
  63. N. J. Welton, I. R. White, G. Lu, J. P. Higgins, J. Hilden, and A. E. Ades, “Correction: interpretation of random effects meta-analysis in decision models,” Medical Decision Making, vol. 27, no. 2, pp. 212–214, 2016. View at Publisher · View at Google Scholar
  64. C. B. Begg and M. Mazumdar, “Operating characteristics of a rank correlation test for publication bias,” Biometrics, vol. 50, no. 4, pp. 1088–1101, 1994. View at Publisher · View at Google Scholar · View at Scopus
  65. M. Egger, G. D. Smith, M. Schneider, and C. Minder, “Bias in meta-analysis detected by a simple, graphical test,” British Medical Journal, vol. 315, pp. 629–634, 1997. View at Publisher · View at Google Scholar · View at Scopus
  66. N. Orsini, R. Bellocco, and S. Greenland, “Generalized least squares for trend estimation of summarized dose-response data,” Stata Journal, vol. 6, no. 1, pp. 40–57, 2006. View at Publisher · View at Google Scholar · View at Scopus
  67. S. Greenland and M. P. Longnecker, “Methods for trend estimation from summarized dose-response data, with applications to meta-analysis,” American Journal of Epidemiology, vol. 135, no. 11, pp. 1301–1309, 1992. View at Publisher · View at Google Scholar · View at Scopus
  68. P. Royston, “A strategy for modelling the effect of a continuous covariate in medicine and epidemiology,” Statistics in Medicine, vol. 19, no. 14, pp. 1831–1847, 2000. View at Publisher · View at Google Scholar · View at Scopus
  69. V. Bagnardi, A. Zambon, P. Quatto, and G. Corrao, “Flexible meta-regression functions for modeling aggregate dose-response data, with an application to alcohol and mortality,” American Journal of Epidemiology, vol. 159, no. 11, pp. 1077–1086, 2004. View at Publisher · View at Google Scholar · View at Scopus
  70. M. Mendilaharsu, E. De Stefani, H. Deneo-Pellegrini, J. Carzoglio, and A. Ronco, “Phytosterols and risk of lung cancer: a case-control study in Uruguay,” Lung Cancer, vol. 21, no. 1, pp. 37–45, 1998. View at Publisher · View at Google Scholar
  71. A. Ronco, E. De Stefani, P. Boffetta, H. Deneo-Pellegrini, M. Mendilaharsu, and F. Leborgne, “Vegetables, fruits, and related nutrients and risk of breast cancer: a case-control study in Uruguay,” Nutrition and Cancer, vol. 35, no. 2, pp. 111–119, 1999. View at Publisher · View at Google Scholar · View at Scopus
  72. S. E. McCann, J. L. Freudenheim, J. R. Marshall, Brasure. J. R., M. K. Swanson, and S. Graham, “Diet in the epidemiology of endometrial cancer in western New York (United States),” in Cancer Causes and Control, vol. 11, pp. 965–974, 10 edition, 2000. View at Publisher · View at Google Scholar
  73. E. De Stefani, E. Brennan, P. Boffetta, A. L. Ronco, M. Mendilaharsu, and H. Deneo-Pellegrini, “Vegetables, fruits, related dietary antioxidants, and risk of squamous cell carcinoma of the esophagus: a case-control study in Uruguay,” Nutrition and Cancer, vol. 38, no. 1, pp. 23–29, 2000. View at Publisher · View at Google Scholar · View at Scopus
  74. E. De Stefani, P. Boffetta, A. L. Ronco et al., “Plant-sterols and risk of stomach cancer: a case-control study in Uruguay,” Nutrition and Cancer, vol. 37, no. 2, pp. 140–144, 2000. View at Publisher · View at Google Scholar · View at Scopus
  75. A. L. Normén, H. A. Brants, L. E. Voorrips, H. A. Andersson, P. A. van den Brandt, and R. A. Goldbohm, “Plant sterol intakes and colorectal cancer risk in the netherlands cohort study on diet and cancer,” American Journal of Clinical Nutrition, vol. 74, no. 1, pp. 141–148, 2001. View at Publisher · View at Google Scholar
  76. F. L. Walcott, M. Hauptmann, C. M. Duphorne, P. C. Pillow, S. S. Strom, and A. J. Sigurdson, “A case-control study of dietary phytoestrogens and testicular cancer risk,” Nutrition and Cancer, vol. 44, no. 1, pp. 44–51, 2002. View at Publisher · View at Google Scholar · View at Scopus
  77. S. E. McCann, J. L. Freudenheim, J. R. Marshall, and S. Graham, “Risk of human ovarian cancer is related to dietary intake of selected nutrients, phytochemicals and food groups,” Journal of Nutrition, vol. 133, no. 6, pp. 1937–1942, 2003. View at Publisher · View at Google Scholar · View at Scopus
  78. M. B. Schabath, L. M. Hernandez, X. Wu, P. C. Pillow, and M. R. Spitz, “Dietary phytoestrogens and lung cancer risk,” Journal of the American Medical Association, vol. 294, pp. 1493–1504, 2005. View at Publisher · View at Google Scholar
  79. S. E. McCann, C. B. Ambrosone, K. B. Moysich et al., “Intakes of selected nutrients, foods, and phytochemicals and prostate cancer risk in Western New York,” Nutrition and Cancer, vol. 53, no. 1, pp. 33–41, 2005. View at Publisher · View at Google Scholar · View at Scopus