Circular RNA hsa_circRNA_0007334 is Predicted to Promote MMP7 and COL1A1 Expression by Functioning as a miRNA Sponge in Pancreatic Ductal Adenocarcinoma
Figure 10
Expression profiles of hsa_circRNA_0007334, MMP7, and COL1A1 in the PANC-1 cell line after hsa_circRNA_0007334 knockdown. (a) The expression levels of hsa_circRNA_0007334 in the negative control (NC) and hsa_circRNA_0007334 knockdown groups. (b) The mRNA expression levels of MMP7 in the NC, hsa_circRNA_0007334 knockdown, and knockdown plus miR-144-3p inhibitor groups. (c) The mRNA expression levels of COL1A1 in the NC, hsa_circRNA_0007334 knockdown, and knockdown plus miR-577 inhibitor groups. (d) Western blot results of MMP7 and COL1A1 expression in the NC, hsa_circRNA_0007334 knockdown, and knockdown plus miRNA inhibitor groups. (e) The protein expression levels of MMP7 in the NC, hsa_circRNA_0007334 knockdown, and knockdown plus miR-144-3p inhibitor groups. (f) The protein expression levels of COL1A1 in the NC, hsa_circRNA_0007334 knockdown, and knockdown plus miR-577 inhibitor groups. indicates a significant difference compared to the NC group (p<0.05).