Journal of Oncology / 2019 / Article / Fig 2

Research Article

Circular RNA hsa_circRNA_0007334 is Predicted to Promote MMP7 and COL1A1 Expression by Functioning as a miRNA Sponge in Pancreatic Ductal Adenocarcinoma

Figure 2

GO and KEGG analyses of the parental gene function of the differentially expressed circRNAs. (a) GO analysis covers the three domains of biological process, cellular component, and molecular function. The x-axis presents the gene number and the proportion of all annotated genes, and the y-axis presents the top 15 functions in each term. (b) KEGG analysis revealed the most important biochemical metabolic pathways and signal transduction pathways in which the genes are involved. The x-axis presents the Rich factor in this pathway, the y-axis presents the related pathways, the q values are represented in different colors, and the size of the circle represents the number of genes in this pathway. The degree of KEGG enrichment is measured by the Rich factor, the q value, and the number of genes in this pathway. The Rich factor refers to the ratio of the number of differentially expressed genes located in the pathway to the total number of genes in the pathway. The larger the Rich factor, the greater the degree of enrichment. The q value is the p value after the multiplicative hypothesis test and correction, and the value range of the q value is 0-1. The closer the value to 0, the more significant the enrichment.


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