Research Article
MicroRNA Expression Changes in Women with Breast Cancer Stratified by DNA Repair Capacity Levels
Table 2
Clinicopathological characteristics of BC cases with low and high levels of DNA repair capacity.
| | Clinicopathological Characteristics | Low DRC (<3.8%) | High DRC (≥3.8%) | p-value | | n=18 (%) | n=9 (%) |
| | Estrogen receptor status | | | | | Positive | 9 (33.3) | 3 (11.1) | 0.5698 | | Negative | 6 (22.2) | 3 (11.1) | | | Missing | 3 (11.1) | 3 (11.1) | | | Progesterone receptor status | | | | | Positive | 8 (29.6) | 3 (11.1) | 0.6121 | | Negative | 7 (25.9) | 3 (11.1) | | | Missing | 3 (11.1) | 3 (11.1) | | | HER2 status | | | | | Positive | 0 (0.0) | 1 (3.7) | 0.7160 | | Negative | 12 (44.4) | 5 (18.5) | | | Missing | 6 (22.2) | 3 (11.1) | | | Ki-67 | | | | | Low (≤10%) | 1 (3.7) | 1 (3.7) | 0.9297 | | Borderline (11-20%) | 0 (0.0) | 0 (0.0) | | | High (≥21%) | 3 (11.1) | 1 (3.7) | | | Missing | 15 (55.6) | 6 (22.2) | | | Grade | | | | | I | 4 (14.8) | 0 (0.0) | 0.4194 | | II | 6 (22.2) | 4 (14.8) | | | III | 5 (18.5) | 4 (14.8) | | | Missing | 3 (11.1) | 1 (3.7) | | | Molecular Subtypes | | | | | Luminal A | 7 (25.9) | 3 (11.1) | 0.6923 | | Luminal B | 0 (0.0) | 0 (0.0) | | | HER2+ | 0 (0.0) | 1 (3.7) | | | Triple-negative | 5 (18.5) | 2 (7.4) | | | Missing | 6 (22.2) | 3 (11.1) | | | Site | | | | | Ductal | 16 (59.3) | 7 (25.9) | 0.3522 | | Lobular | 2 (7.4) | 1 (3.7) | | | Ductal + Lobular | 0 (0.0) | 1 (3.7) | | | Type | | | | | In situ | 1 (3.7) | 0 (0.0) | 0.4712 | | Invasive | 17 (63.0) | 9 (33.3) | |
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Pearson’s chi-square test was performed to assess significance among groups.
DRC: DNA repair capacity, BMI: body mass index, BC: breast cancer.
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