Journal of Oncology

Research Article

MicroRNA Expression Changes in Women with Breast Cancer Stratified by DNA Repair Capacity Levels

Table 3

Breast cancer-related miRNAs and comparisons with women with low and high DRC levels.


miRNA ID	Case-Control	Regulation	DRC	Multiple Comparisons	p-value³
miRNA ID	Groups¹	Regulation	Groups²	Multiple Comparisons	p-value³

let-7b	0.0153	↑	0.1062	-	-
let-7c	0.0157	↑	0.0581	-	-
let-7e	0.0477	↑	0.2243	-	-
miR-101-3p	0.0389	↑	0.1517	-	-
miR-150-5p	0.0258	↑	0.1615	-	-
miR-155-5p	0.0043	↑	0.0329	NS	p>0.05
miR-18a-5p	0.0205	↓	0.1344	-	-
miR-194-5p	0.0083	↑	0.0465	NS	p>0.05
miR-204-5p	0.0337	↑	0.1175	-	-
miR-212-3p	0.0227	↑	0.0857	-	-
miR-222-3p	0.0330	↑	0.1847	-	-
miR-25-3p	0.0455	↑	0.1010	-	-
miR-296-3p	0.0440	↑	0.0322	NS	p>0.05
miR-299-5p	0.0143	↑	0.0362	BC LDRC vs. Controls LDRC	p<0.05
miR-29b-3p	0.0021	↑	0.0168	BC HDRC vs. Controls LDRC	p<0.05
miR-302a-3p	0.0163	↑	0.0616	-	-
miR-302c-3p	0.0022	↑	0.0040	BC LDRC vs. Controls LDRC	p<0.01
miR-30b-5p	0.0258	↑	0.1107	-	-
miR-320a-3p	0.0492	↑	0.2296	-	-
miR-323-3p	0.0002	↑	0.0014	BC cases LDRC vs. Controls (LDRC & HDRC)	p<0.05
miR-331-5p	0.0124	↑	0.0145	BC LDRC vs. Controls LDRC	p<0.05
miR-342-3p	0.0065	↑	0.0297	NS	p>0.05
miR-363-3p	0.0227	↑	0.0394	BC LDRC vs. Controls LDRC	p<0.05
miR-367-3p	0.0046	↑	0.0235	BC LDRC vs. Controls HDRC	p<0.05
miR-372-3p	0.0024	↓	0.0254	NS	p>0.05
miR-373-3p	0.0006	↑	0.0077	BC LDRC vs. Controls LDRC	p<0.01
miR-375-3p	0.0175	↑	0.1060	-	-
miR-383-5p	0.0135	↑	0.0849	-	-
miR-425-5p	0.0165	↑	0.0540	-	-
miR-483-5p	0.0121	↑	0.0386	NS	p>0.05
miR-486 -5p	0.0234	↑	0.1370	-	-
miR-509-5p	0.0226	↑	0.1330	-	-
miR-518f-3p	0.0002	↑	0.0011	BC cases LDRC vs. Controls (LDRC&HDRC)	p<0.01
miR-520b-3p	0.0084	↑	0.0615	-	-
miR-525-5p	0.0055	↑	0.0537	-	-
miR-597-5p	0.0029	↑	0.0073	BC LDRC vs. Controls LDRC	p<0.01
miR-628-5p	0.0003	↑	0.0026	BC cases LDRC vs. Controls (LDRC&HDRC)	p<0.05
miR-636	0.0205	↑	0.0266	BC cases LDRC vs. Controls HDRC	p<0.05
miR-652-3p	0.0423	↓	0.2382	-	-
miR-708-5p	0.0187	↑	0.1298	-	-

p-value¹: obtained from Mann–Whitney test (BC case-control comparisons); p-value²: obtained from Kruskal–Wallis test (DRC stratifications); p-value³: obtained from Dunn’s multiple comparisons post hoc test. NS: nonsignificant, BC: breast cancer, LDRC: low DNA repair capacity, HDRC: high DNA repair capacity. Arrows represent up- or downregulation in BC cases when compared to controls.
means groups significantly different from post hoc analysis.