Review Article
Current Landscape of Epigenetics in Lung Cancer: Focus on the Mechanism and Application
Table 1
Abnormally methylated genes in lung cancer.
| Gene | Mechanism | Epigenetic modification | References |
| RASSF1A | DNA repair; cell cycle | Hypermethylation | [40,41] | MGMT | DNA repair | Hypermethylation | [45] | CDKN2A/p16 | Cell cycle | Hypermethylation | [51,52] | DAPK | Apoptosis; autophagy | Hypermethylation | [34–36,59,60] | P14 | Proliferation; apoptosis | Hypermethylation | [20] | OTUD4 | Cell cycle; apoptosis; DNA repair | Hypermethylation | [81,96,97] | CDH1/E-cadherin | EMT | Hypermethylation | [98,99] | RARβ | Metastasis | Hypermethylation | [27,100–102] | RUNX3 | TGF-β/Wnt signaling pathway | Hypermethylation | [103–106] | APC | Wnt/β-catenin signaling pathway | Hypermethylation | [107–109] |
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