Current Landscape of Epigenetics in Lung Cancer: Focus on the Mechanism and Application

Table 2

LncRNAs deregulated in lung cancer.

LncRNA	Mechanism	Clinical utility	Expression	References
HOTAIR	Invasion; metastasis	Prognostic biomarker; therapeutic target	Upregulated	[28–30,67]
H19	Proliferation; migration; invasion	Prognostic biomarker	Upregulated	[110–112]
MALAT1	Migration; invasion; chemoresistance	Predictive biomarker	Upregulated	[24,113,114]
ANRIL	Proliferation; apoptosis; cell cycle	Prognostic biomarker	Upregulated	[115,116]
LINC00668	Proliferation; migration; invasion; apoptosis.	Prognostic biomarker	Upregulated	[25,117]
LINC01436	Metastasis	Prognostic biomarker	Upregulated	[31]
SUMO1P3	Metastasis	Therapeutic target	Upregulated	[32]
MNX1-AS1	Proliferation; migration; apoptosis	Prognostic biomarker	Upregulated	[21]
RHPN1-AS1	Gefitinib resistance	Prognostic biomarker; therapeutic target	Downregulated	[118]
MIR31HG	Cell cycle; proliferation	Prognostic biomarker	Upregulated	[119]