Review Article
Current Landscape of Epigenetics in Lung Cancer: Focus on the Mechanism and Application
Table 2
LncRNAs deregulated in lung cancer.
| LncRNA | Mechanism | Clinical utility | Expression | References |
| HOTAIR | Invasion; metastasis | Prognostic biomarker; therapeutic target | Upregulated | [28ā30,67] | H19 | Proliferation; migration; invasion | Prognostic biomarker | Upregulated | [110ā112] | MALAT1 | Migration; invasion; chemoresistance | Predictive biomarker | Upregulated | [24,113,114] | ANRIL | Proliferation; apoptosis; cell cycle | Prognostic biomarker | Upregulated | [115,116] | LINC00668 | Proliferation; migration; invasion; apoptosis. | Prognostic biomarker | Upregulated | [25,117] | LINC01436 | Metastasis | Prognostic biomarker | Upregulated | [31] | SUMO1P3 | Metastasis | Therapeutic target | Upregulated | [32] | MNX1-AS1 | Proliferation; migration; apoptosis | Prognostic biomarker | Upregulated | [21] | RHPN1-AS1 | Gefitinib resistance | Prognostic biomarker; therapeutic target | Downregulated | [118] | MIR31HG | Cell cycle; proliferation | Prognostic biomarker | Upregulated | [119] |
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