Current Landscape of Epigenetics in Lung Cancer: Focus on the Mechanism and Application

Table 3

miRNAs deregulated in lung cancer.

miRNA	Mechanism	Clinical utility	Expression level	References
miR-21	Apoptosis	Prognostic biomarker; therapeutic target	Upregulated	[70,120]
miR-495	Proliferation; migration; invasion; EMT; drug resistance	Therapeutic target	Downregulated	[22]
miR-661	Invasion; metastasis	Therapeutic target	Upregulated	[72,121]
miR-3607-3p	Cell cycle; metastasis	Prognostic biomarker; therapeutic target	Downregulated	[122]
miR-181b	Migration; invasion	Therapeutic target	Downregulated	[26]
miR -19	Proliferation; migration	Therapeutic target	Upregulated	[23]
miR-182	Cell cycle; apoptosis	Diagnostic/prognostic biomarker	Upregulated	[123]
miR-505-5p	Proliferation; apoptosis	Diagnostic biomarker	Upregulated	[124]
miR-1290	Metastasis	Prognostic biomarker	Upregulated	[125]
miR-CHA1	Proliferation; apoptosis	Therapeutic target	Downregulated	[126]
miR-193a-3p, miR-210-3p, miR-5100	Metastasis; EMT	Diagnostic biomarker	Upregulated	[33]
miR-374b	Apoptosis	Therapeutic target	Downregulated	[37]