Tubal Origin of “Ovarian” Low-Grade Serous Carcinoma: A Gene Expression Profile Study

Table 2

Immunohistochemistry scores of differentially expressed biomarkers.

	FTE	OEI	SC	SBT	LGSC	OSE
VGP1	280±20	218±17	196±16	226±21	164±18	12±5
WT-1	290±10	280±18	280±20	260±10	290±10	78±22
FMO3	220±18	180±26	168±28	200±30	210±24	10±8
ARX	20±10	30±12	40±10	60±20	40±24	250±30
FCN1	30±6	20±10	20±10	20±10	60±20	280±10

FTE, fallopian tubal epithelia; OEI, ovarian epithelial inclusions; SC, serous cystadenoma; SBT, serous borderline tumor; LGSC, low-grade serous carcinoma; OSE, ovarian surface epithelia.
Compared to OSE samples, the expression level of OVGP1, WT-1, and FMO3 was significantly higher in tissues of FTE, OEI, SC, SBT, and LGSC (p < 0.0001), while no statistical differences were detected among the samples of FTE, OEI, SC, SBT, and LGSC. Compared to FTE, OEI, SC, SBT, and LGSC samples, the expression level of ARX and FCN1 was significantly higher in OSEs (p < 0.0001), while no statistical differences were detected among the samples of FTE, OEI, SC, SBT, and LGSC.