Notch Signaling Activation as a Hallmark for Triple-Negative Breast Cancer Subtype

Figure 1

Role of Notch signaling in TNBC. (a) Schematic representation of the Notch receptors structure. Abbreviations. NECD: Notch extracellular domain; NTM: Notch transmembrane; NICD: Notch intracellular domain; EGF: epidermal growth factor-like repeats; NRR: negative regulatory region; LNR: Lin12/Notch repeats; HD: heterodimerization domain; PM: plasmatic membrane; RAM: RBP-j associated molecule; NLS: nuclear localization signal; ANK: ankyrin repeats; PEST: proline (P), glutamic acid (E), serine (S), and threonine (T). (b) The cartoon schematically depicts the involvement of each Notch receptor on TNBC initiation and progression.

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