The Role of MicroRNA in Paediatric Acute Lymphoblastic Leukaemia: Challenges for Diagnosis and Therapy

Figure 1

The functional mechanism of miRNA in posttranscriptional regulation of gene expression. miRNAs function to regulate the expression of genes by binding to the 3′ untranslated regions of their target messenger RNAs (mRNAs). miRNAs downregulate expression through acceleration of the degradation of mRNA (perfect complementarity) or by inhibition of its translation (imperfect complementarity).