AURKA rs8173 G>C Polymorphism Decreases Wilms Tumor Risk in Chinese Children
Table 3
Frequency of inferred haplotypes of the AURKA gene based on observed genotypes and their association with the risk of Wilms tumor.
Haplotypesa
Cases (n = 286)
Controls (n = 1062)
Crude OR (95% CI)
AOR (95% CI)b
CAC
62 (21.68)
279 (26.27)
1.00
1.00
CAG
17 (5.94)
36 (3.39)
2.00 (1.06–3.77)
0.033
1.99 (1.05–3.77)
0.034
CTC
18 (6.29)
86 (8.10)
0.89 (0.50–1.57)
0.676
0.91 (0.51–1.62)
0.748
CTG
153 (53.50)
533 (50.19)
1.21 (0.88–1.68)
0.240
1.21 (0.88–1.67)
0.249
TAC
8 (2.80)
34 (3.20)
1.00 (0.44–2.25)
0.990
0.99 (0.44–2.24)
0.983
TAG
2 (0.70)
11 (1.04)
0.77 (0.17–3.55)
0.736
0.74 (0.16–3.40)
0.694
TTC
2 (0.70)
8 (0.75)
1.06 (0.22–5.09)
0.945
1.09 (0.23–5.28)
0.913
TTG
24 (8.39)
75 (7.06)
1.35 (0.79–2.30)
0.266
1.34 (0.79–2.29)
0.279
OR, odds ratio; CI, confidence interval; AOR, adjusted odds ratio. aThe haplotype order was rs1047972, rs2273535, and rs8173; bobtained in logistic regression models with adjustment for age and gender.
