LncRNA PVT1 Mediates Antiapoptosis and 5-Fluorouracil Resistance via Increasing Bcl2 Expression in Gastric Cancer
Figure 1
LncRNA PVT1 can regulate the growth of GC. (a) The expression of PVT1 in different stages of GC. A total of 431 samples were included in this dataset. These samples were divided into different subsets according to the tumor stages. The numbers refer to the number of people in the corresponding subsets. (b) This shows the validation of stably overexpressed and silenced PVT1 in SGC-7901 cells via qRT-PCR. PVT1 refers to PVT1 overexpression; CTR indicates the control group of PVT1; shPVT1 represents PVT1 silenced by shRNA; NC indicates the control of shPVT1. (c) This shows the subcutaneous tumors derived from SGC-7901 cells with overexpressed or silenced PVT1 (n=3 for each group). (d, e) This shows that the tumor volumes were measured at the indicated time. (f) This shows the orthotopic malignant tumor from SGC-7901 cells with overexpressed PVT1. Results were measured in triplicate in each experiment. P < 0.05.