LncRNA PVT1 Mediates Antiapoptosis and 5-Fluorouracil Resistance via Increasing Bcl2 Expression in Gastric Cancer
Figure 2
LncRNA PVT1 can regulate the apoptosis of GC. (a, b) This shows the clone formation assay of SGC-7901 with overexpressed and silenced PVT1. (c) The apoptosis cells were assessed using flow cytometry assay in PVT1 overexpressed and silenced SGC-7901 cells. (d) shows the quantitative results of the flow cytometry assay demonstrating the percentage of apoptotic cells. (e, g) TUNEL assay to detect apoptotic cells in xenografts tissues. The green cells indicate the TUNEL-positive apoptotic cells. The images of TUNEL-positive cells were captured by fluorescence microscope (400×). (f) Quantitative results of TUNEL assay of subcutaneous tumors tissues. (h) Quantitative results of TUNEL assay of orthotopic tumor tissues. All of the data shown represent the mean ± SD of three independent experiments. P < 0.05.