CXCL12 and Its Isoforms: Different Roles in Pancreatic Cancer?

Figure 1

CXC chemokine structure. Chemokine presents three antiparallel β-sheets and a C-terminal α-helix; this tertiary structure is owing to the presence, starting from N-terminal region, of an “N-loop”, a single 3₁₀ helix, and then the 30s and 40s loops. The two cysteine residues at the N-terminal end allow the formation of disulphide bonds which are fundamental to the chemokine structure and receptor interaction.