Clinicopathological Characteristics and Prognosis of Proximal and Distal Gastric Cancer during 1997–2017 in China National Cancer Center

Table 3

Multivariate survival analysis by tumor location.

Prognostic; Factors	Total (n=11,944)				PGC group (n=4,716)				DGC group (n=7,228)
	HR	95% CI		P Value	HR	95% CI		P Value	HR	95% CI		P Value
		Lower	Upper			Lower	Upper			Lower	Upper
Alcohol consumption
Never drinkers	1.00				1.00				1.00
Current drinkers	0.94	0.87	1.01	0.08	0.98	0.88	1.09	0.69	0.90	0.81	0.99	0.034
Ex-drinkers	0.74	0.61	0.89	0.002	0.81	0.62	1.07	0.14	0.72	0.56	0.93	0.012
BMI (kg/m2)
<18.5	1.07	0.95	1.22	0.26	1.29	1.06	1.58	0.011	0.96	0.82	1.13	0.61
18.5-22.9	1.00				1.00				1.00
23-27.4	0.89	0.83	0.96	0.002	0.80	0.71	0.90	<0.001	0.96	0.88	1.06	0.44
≥27.5	0.91	0.82	1.01	0.09	0.94	0.80	1.09	0.41	0.87	0.75	1.01	0.07
H. pylori
No	1.00				1.00				1.00
Yes	1.43	1.13	1.81	0.003	1.35	0.94	1.94	0.11	1.52	1.11	2.07	0.009
Unknown	1.73	1.44	2.08	<0.001	1.62	1.23	2.13	<0.001	1.82	1.43	2.33	<0.001
Pathologic T stage
T0+Tis	1.66	0.72	3.85	0.23	2.36	0.56	9.94	0.24	1.47	0.52	4.17	0.46
T1	1.00				1.00				1.00
T2	1.53	1.05	2.24	0.028	0.82	0.41	1.62	0.57	1.89	1.19	3.00	0.007
T3	2.65	1.86	3.76	<0.001	1.47	0.79	2.73	0.22	3.20	2.08	4.91	<0.001
T4	3.28	2.32	4.64	<0.001	1.99	1.08	3.69	0.028	3.77	2.47	5.75	<0.001
TX	2.97	2.02	4.36	<0.001	1.46	0.76	2.81	0.26	3.88	2.42	6.23	<0.001
Pathologic N stage
N0	1.00				1.00				1.00
N1	1.36	1.17	1.59	<0.001	1.36	1.09	1.69	0.007	1.37	1.10	1.69	0.0041
N2	1.99	1.73	2.30	<0.001	1,98	1.61	2.44	<0.001	2.00	1.65	2.44	<0.001
N3	3.44	3.01	3.92	<0.001	3.29	2.70	4.01	<0.001	3.58	2.99	4.28	<0.001
NX	1.83	1.41	2.38	<0.001	1.60	1.04	2.48	0.034	1.91	1.36	2.67	<0.001
Pathologic M stage
M0	1.00				1.00				1.00
M1	3.05	2.59	3.59	<0.001	3.65	2.75	4.86	<0.001	2.84	2.32	3.48	<0.001
Lauren classification
Intestinal	1.00				1.00				1.00
Diffuse	1.22	1.03	1.43	0.018	1.21	0.95	1.55	0.12	1.32	1.04	1.67	0.024
Mixed	0.99	0.83	1.19	0.94	1.06	0.83	1.35	0.65	0.96	0.73	1.27	0.78
Unknown	1.30	1.11	1.52	<0.001	1.20	0.97	1.49	0.095	1.44	1.14	1.82	0.003
Type of gastrectomy
Gastrectomy	1.00				1.00				1.00
No surgery	1.43	1.22	1.67	<0.001	1.48	1.15	1.90	0.003	1.44	1.17	1.76	<0.001
Surgical Margin
Negative	1.00				1.00				1.00
Positive on the proximal margin	1.49	1.14	1.94	0.004	1.24	0.84	1.83	0.29	1.67	1.16	2.41	0.006
Positive on the distal margin	1.54	1.19	1.99	0.001	1.53	1.00	2.34	0.051	1.57	1.13	2.17	0.007
Positive on the proximal and distal margin	0.95	0.52	1.72	0.85	0.70	0.17	2.82	0.62	1.10	0.57	2.14	0.77
HER2 score
0 (-)	1.00				1.00				1.00
1 (+)	0.97	0.85	1.10	0.62	0.82	0.67	1.01	0.06	1.08	0.91	1.29	0.37
2 (++)	0.92	0.76	1.11	0.39	0.80	0.61	1.04	0.09	1.02	0.78	1.33	0.88
3 (+++)	1.16	0.93	1.45	0.19	1.13	0.84	1.52	0.43	1.15	0.82	1.61	0.42
Unknown	1.33	1.17	1.50	<0.001	1.19	0.98	1.45	0.07	1.44	1.23	1.70	<0.001
Linitis plastica
No	1.00				1.00				1.00
Yes	1.37	1.01	1.86	0.045	2.13	1.25	3.65	0.006	1.18	0.81	1.73	0.38
Borrmann classification
Borrmann I	1.00				1.00				1.00
Borrmann II	0.92	0.80	1.07	0.30	0.87	0.72	1.06	0.17	0.99	0.78	1.25	0.93
Borrmann III	0.98	0.84	1.14	0.75	0.90	0.74	1.10	0.29	1.06	0.83	1.35	0.62
Borrmann IV	1.44	1.21	1.71	<0.001	1.44	1.12	1.85	0.005	1.48	1.14	1.93	0.003
Unknown	1.12	0.95	1.32	0.17	1.05	0.84	1.32	0.68	1.19	0.93	1.52	0.17
Site
PGC	1.00
DGC	0.94	0.88	1.00	0.058