Galectin-3 Regulates the Expression of Tumor Glycosaminoglycans and Increases the Metastatic Potential of Breast Cancer

<div>Downregulation of Galectin-3 in breast cancer cells decreases the expression of GAGs both <i>in vitro</i> and <i>in vivo</i>. (a) Cytochemistry for glycosaminoglycans (Alcian blue) in 4T1-scramble cells and 4T1-shRNA-Gal-3 cells. (b) Quantification of glycosaminoglycans by cytochemical analysis. (c) Histochemistry for glycosaminoglycans (Alcian blue) in primary tumors developed by 4T1-scramble cells and 4T1-shRNA-Gal-3 cells in Lgals3<sup>+/+</sup> and Lgals3<sup>−/−</sup> mice. (d) Quantification of glycosaminoglycans by histochemical analysis. Data are representative of two independent experiments using 3–5 animals per experiment (c, d). 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Journal of Oncology

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Figure 4

Figure 4: Galectin-3 Regulates the Expression of Tumor Glycosaminoglycans and Increases the Metastatic Potential of Breast Cancer 