Galectin-3 Regulates the Expression of Tumor Glycosaminoglycans and Increases the Metastatic Potential of Breast Cancer

<div>Galectin-3 knockdown decreases syndecan-1 expression. (a) Immunostaining for syndecan-1 in 4T1-scramble cells and 4T1-shRNA-Gal-3 cells. (b) Quantitative PCR for syndecan-1 in 4T1-scramble cells and 4T1-shRNA-Gal-3 cells. (c) Immunostaining for syndecan-1 in primary tumors developed by 4T1-scramble cells and 4T1-shRNA-Gal-3 cells in Lgals3<sup>+/+</sup> and Lgals3<sup>−/−</sup> mice. (d) Quantitative PCR for syndecan-1 in primary tumors developed by 4T1-scramble cells and 4T1-shRNA-Gal-3 cells in Lgals3<sup>+/+</sup> and Lgals3<sup>−/−</sup> mice. Data are representative of two independent experiments using 3–5 animals per experiment (c, d). 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Journal of Oncology

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Figure 6

Figure 6: Galectin-3 Regulates the Expression of Tumor Glycosaminoglycans and Increases the Metastatic Potential of Breast Cancer 