PKHB1 Tumor Cell Lysate Induces Antitumor Immune System Stimulation and Tumor Regression in Syngeneic Mice with Tumoral T Lymphoblasts

Figure 6

PKHB1-TCL therapeutic vaccination induces long-term antitumor memory. Mice in remission after therapeutic vaccinations were rechallenged with 2x10⁶ L5178Y-R viable cells. (a) Graph indicates tumor growth in control mice (control, n = 6) or mice in remission after a previous treatment with PKHB1-TCL that were rechallenged with living L5178Y-R cells (PKHB1-TCL-Rechallenge, n= 6). (b) Kaplan-Meier survival graph of mice treated as in (a) over time. Control: n = 6; PKHB1-TCL-Rechallenge, n= 6.

(a)

(b)