Journal of Oncology / 2020 / Article / Tab 1

Research Article

Comparison of Transcatheter Arterial Chemoembolization-Radiofrequency Ablation and Transcatheter Arterial Chemoembolization Alone for Advanced Hepatocellular Carcinoma with Macrovascular Invasion Using Propensity Score Analysis: A Retrospective Cohort Study

Table 1

Baseline characteristics of patients before matching.

VariablesControlTACE valueTACE + RFA value
(n = 269)(n = 254)(n = 141)

Median age (range)55 (25–81)55 (25–78)0.695a)56 (28–78)0.241a)
Sex (M/F)231/38217/370.886b)117/240.437b)
Family history of HCC (yes/no)38/23130/2240.431b)15/1260.317b)
HBV related (yes/no)248/21233/210.846b)129/120.803b)
GGT (IU/L)185.3 (90.7–322.2)125.5 (80.3–181.1)<0.001c)95.2 (59.5–143.4)<0.001c)
WBC (×109/L)5.0 (3.6–6.6)4.6 (3.3–5.9)0.027c)4.5 (3.5–6.5)0.559c)
PLT (×109/L)108.4 (69.9–158.8)93.1 (62.0–144.3)0.068c)112.9 (64.0–161.6)0.747c)
AFP (ng/mL) (≥400/<400)138/131114/1400.142b)55/860.018b)
PVTT (%)226 (84.0)211 (83.1)0.849b)117 (83.0)0.849b)
HVTT (%)12 (4.5)14 (5.5)0.757b)7 (5.0)0.987b)
PVTT + HVTT (%)31 (11.5)29 (11.4)0.844b)17 (12.1)0.979b)
Tumor number (≥3/<3)160/109111/143<0.001b)48/93<0.001b)
Tumor diameter (cm) (≥5/<5)167/102154/1000.733b)77/640.143b)
Child-Pugh class (A/B or C)69/200133/121<0.001b)89/52<0.001b)
MELD score9.1 (5.3–11.9)6.4 (3.9–8.4)<0.001c)6.0 (3.0–8.3)<0.001c)
TNM (III/IV)221/48211/430.783b)125/160.085b)
BCLC (C/D)202/67225/29<0.001b)129/12<0.001b)

Age is presented as median (range), categorical variables as number (%), continuous variable as mean (interquartile range). a), t-test; b), chi-square test or Fisher’s exact test; c), Mann–Whitney U test. HBV, hepatitis B virus; GGT, gamma-glutamyl transferase; WBC, white blood cell count; PLT, platelet count; AFP, α-fetoprotein; PVTT, portal vein tumor thrombosis; HVTT, hepatic vein tumor thrombosis; MELD, model for end-stage liver disease; TNM, tumor, node, and metastasis staging; BCLC, Barcelona Clinic for Liver Cancer.

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