EGFR Polymorphism and Survival of NSCLC Patients Treated with TKIs: A Systematic Review and Meta-Analysis

Table 1

General characteristics of the included studies.

Author, year	Country	Study period	No. of patients	Median age, years (range)	Gender (males, %)	Ethnicity (%)	Smokers (%)	Clinical stage (%)	Median follow-up in months	TKI (dose)	Additional therapy
Han et al., 2007 [55]	Korea	Jan 2002–Dec 2004	86	61 (30–87)	57.0	NR	55.8	IIIB (5.8); IV (94.2)	16.9	Gefitinib (250 mg/d)	NR
Ichihara et al., 2007 [26]	Japan	Nov 2000–May 2006	98	66 (NR)	63.0	NR	62.0	NR^b	11.4^c	Gefitinib (250 mg/d)	88.0% of patients previously treated with chemotherapy
Liu et al., 2008 [56]	USA and Canada	Dec 2000–Feb 2003	92	61 (36–87)	41.0	Caucasian (95); Asian (3); African American (2)	79.0	IIIB (7.0); IV (93.0)	28.5 (PFS); 29.9 (OS)	Gefitinib (NR)	85.0% of patients were previously, and 95% concurrently treated with chemotherapy
Giovannetti et al., 2010 [57]	Italy	NR	96	64 (NR)	57.3	NR	68.8	IIIB (9.4); IV (90.6)	NR	Gefitinib (250 mg/d)	84.5% of patients were previously treated with chemotherapy^d
Tiseo et al., 2010 [58]	Italy	NR	91	67 (40–85)	61.5	Caucasian (100)	78.0	III (11.0); IV (89.0)	NR	Gefitinib (250 mg/d)	All patients were previously treated with chemotherapy
Nie et al., 2011 [60]	China	Jun 2002–Sep 2006–Jul 2010^a	115^e	57 (NR)	56.5	NR	NR	IV (83.5)	54.0	Gefitinib (250 mg/d) or erlotinib (150 mg/d)	All patients were previously treated with chemotherapy
Jung et al., 2012 [25]	Korea	Jan 2007–Dec 2010	71^f	59 (34–85)	62.0	Asian (100)	57.7	NR	12.7	Gefitinib (250 mg/d) or erlotinib (150 mg/d)	All patients were previously treated with chemotherapy
Zhang et al., 2013 [31]	China	Jan 2008–Dec 2010	128	55 (32–80)	48.4	NR	32.0	IIIB (25.0); IV (75.0)	16.6	Gefitinib (250 mg/d)	All patients were previously treated with one or two other therapy options
Winther-Larsen et al., 2014 [59]	Denmark	Jan 2007–Oct 2011	62^g	65 (33–88)	40.0	Caucasian (100)	16.0	IV (100)	52.2	Erlotinib (150 mg/d, dose reduced in case of side effects grade 2 or higher)	NR
Winther-Larsen et al., 2015 [32]	Denmark	Jan 2007–Apr 2014	331	64 (34–89)	46.0	Caucasian (100)	26.0	IV (100)	62.7	Erlotinib (150 mg/d, dose reduced in case of side effects grade 2 or higher)	84.0% and 10% of patients were previously treated with platinum-based and pemetrexed and/or docetacel-based chemotherapy, respectively
Kim et al., 2017 [61]	Italy and Canada	NR	760	62 (27–81)	66.3	East Asian (3.2); other (96.8)	79.3	IIIB (10.9); IV (89.1)	36.0	Erlotinib (150 mg/d)	50% of patients were treated with erlotinib, followed by cisplatin and gemcitabine at progression; other 50% were treated with cisplatin and gemcitabine, followed by erlotinib at progression

NR: not reported. ^aLast follow-up. ^bBased on the Eastern Cooperative Oncology Group performance status, there were 61.0% with grade 0/1 and 39.0% with grade 2/3/4. ^cFor survivors. ^dAdditional 127 chemotherapy-treated/gefitinib-nontreated NSCLC patients were used as a comparison. ^e70 on gefitinib and 45 on erlotinib. ^f37 on gefitinib and 34 on erlotinib. ^gAll were EGFR mutation positive.