Diagnostic Accuracy of Procalcitonin, Neutrophil-to-Lymphocyte Ratio, and C-Reactive Protein in Detection of Bacterial Infections and Prediction of Outcome in Nonneutropenic Febrile Patients with Lung Malignancy

Table 1

Clinical and demographic characteristics of bacteria-infected group and TF group in NNLCPs with fever.

Characteristics	Bacteria-infected group (N = 311)	TF group (N = 277)
Age, median (range) (years)	65 (35, 87)	64 (28, 84)
Sex
Male n (%)	246 (79.1)	189 (68.2)
Female n (%)	65 (20.9)	88 (31.8)
Pathological type
AC n (%)	131 (42.1)	139 (50.2)
SCC n (%)	106 (34.1)	73 (26.4)
SCLC n (%)	54 (17.4)	56 (20.2)
Others n (%)	20 (6.4)	9 (3.2)
Tumor stage
I n (%)	55 (17.7)	30 (10.8)
II n (%)	18 (5.8)	13 (4.7)
III n (%)	84 (27.0)	82 (29.6)
IV n (%)	135 (43.4)	133 (48.0)
Not available, EMR n (%)	19 (6.1)	19 (6.9)
Hematological parameters
WBC median (range) (10^9/L)	8.87 (0.89, 42.54)	5.57 (0.82, 29.36)
LYM median (range) (10^9/L)	0.83 (0.05, 6.07)	1.11 (0.08, 8.14)
NEU median (range) (10^9/L)	7.15 (0.73, 41.32)	3.82 (0.63, 23.21)
MON median (range) (10^9/L)	0.62 (0.02, 3.83)	0.53 (0.04, 3.51)
RBC median (range) (10^12/L)	3.87 (1.48, 5.50)	4.02 (1.54, 5.72)
Hb median (range) (g/L)	120 (46, 169)	124 (51, 172)
PLT median (range) (10^9/L)	202 (2, 567)	217 (19, 772)
NLR median (range)	8.70 (0.83, 190.38)	3.63 (0.69, 39.00)
PLR median (range)	226.83 (2.38, 1480.00)	189.68 (10.58, 857.14)
LMR median (range)	1.45 (0.18, 62.50)	1.98 (0.31, 22.44)
Microorganism^a
Gram-positive bacteria n (%)	44 (13.8)
Staphylococcus aureus n (%)	20 (6.3)
Streptococcus pneumoniae n (%)	15 (4.7)
Others n (%)	9 (2.8)
Gram-negative bacteria n (%)	274 (86.2)
Klebsiella pneumoniae n (%)	68 (21.4)
Haemophilus influenzae n (%)	58 (18.2)
Pseudomonas aeruginosa n (%)	44 (13.9)
Escherichia coli n (%)	30 (9.4)
Acinetobacter baumannii n (%)	17 (5.4)
Moraxella catarrhalis n (%)	14 (4.4)
Others n (%)	43 (13.5)

^aSeven patients were identified by MDI as having simultaneous infection with two types of bacteria. NNLCPs: nonneutropenic lung cancer patients; TF: tumor fever; AC: adenocarcinoma; SCC: squamous cell carcinoma; SCLC: small cell lung cancer; EMR: electronic medical records; WBC: white blood cell; LYM: lymphocyte; NEU: neutrophil; MON: monocyte; NLR: neutrophil-to-lymphocyte ratio; PLR: platelet-to-lymphocyte ratio; LMR: lymphocyte-to-monocyte ratio; MDI: microbiologically documented infection.