Diagnostic Accuracy of Procalcitonin, Neutrophil-to-Lymphocyte Ratio, and C-Reactive Protein in Detection of Bacterial Infections and Prediction of Outcome in Nonneutropenic Febrile Patients with Lung Malignancy

Table 4

The diagnostic performance comparison of PCT, CRP, WBC, NEU, and NLR in bacteria-infected subgroup A and TF subgroup A.

Diagnostic performance	PCT	CRP	WBC	NEU	NLR
AUC	0.874	0.855	0.729	0.761	0.792
95% CI	0.813–0.935	0.790–0.919	0.639–0.818	0.676–0.846	0.712–0.872
Cut-off value	0.105 ng/mL	12.2 mg/L	5.975 × 10^9 L	6.245 × 10^9 L	7.397
Sensitivity	79.7%	85.5%	78.3%	62.3%	66.7%
Specificity	80.4%	71.4%	64.3%	82.1%	87.5%
PPV	83.3%	78.7%	73.0%	81.1%	86.8%
NPV	76.3%	80.0%	70.6%	63.9%	68.1%
Youden index	0.601	0.569	0.425	0.445	0.542
value	<0.001	<0.001	<0.001	<0.001	<0.001

TF: tumor fever; AUC, area under the ROC curve; PPV: positive predictive value; NPV: negative predictive value; PCT: procalcitonin; CRP: C-reactive protein; WBC: white blood cell; NEU: neutrophil; NLR: neutrophil-to-lymphocyte ratio.