Efficacy and Safety of First-Line Immunotherapy in Combination with Chemotherapy for Patients with Extensive-Stage Small Cell Lung Cancer: A Systematic Review and Network Meta-Analysis

Figure 3

Network meta-analysis of comparisons on different outcomes of first-line treatments in different groups of small cell lung cancer patients. (a) Comparison of overall survival and progression-free survival. (b) Comparison of objective response rate and disease control rate. (c) Comparison of any grade and grade 3 or more adverse events. Direct comparisons are represented by the color lines connecting the treatments. Line width is proportional to the number of trials including every pair of treatments, whereas circle size is proportional to the total number of patients for each treatment in the network. ATE = atezolizumab; DUR = durvalumab; IPI = ipilimumab; PLA = placebo. All these treatments were combined with chemotherapy.

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