Computational Identification of Tumor Suppressor Genes Based on Gene Expression Profiles in Normal and Cancerous Gastrointestinal Tissues

Table 2

Correlations of the expression levels of tumor suppressor genes (TSGs) with immunotherapy response in cancer. Anti-CTLA-4/PD-1 immunotherapy response rates in melanoma patients with high or low expression of three TSGs. Fisher’s exact test values are shown.

Cohorts	Nathanson et al.’s cohort		Roh et al.’s cohort		Roh et al.’s cohort
Gene symbol	GSTA2		MADCAM1		CCL21
Expression	Low	High	Low	High	Low	High
Response (%)	16.67	66.67	29.73	66.67	16.00	61.90
No response (%)	83.33	33.33	70.27	33.33	84.00	38.10
Fisher’s exact test values	0.036		0.058		0.002