High-Dose Vitamin C Tends to Kill Colorectal Cancer with High MALAT1 Expression

Figure 2

High-dose Vitamin C suppresses CRC growth, angiogenesis, and metastasis in mouse xenograft and intraperitoneal implantation metastasis models. (a) General observation of mice in different xenograft groups (SC, SC + Vc low, SC + Vc high) on the sacrificed day. And the tumor size was calculated in a scatter plot (c). (b) The tumor number and size of different groups in the model of intraperitoneal implantation metastasis (IP, IP + Vc low, IP + Vc high). The body weight change in the tumor growth process in xenograft groups (d) and the tumor metastasis process in the intraperitoneal implantation metastasis groups (e). Only a tendency could be obtained due to the individual differences, weighing equipment, and the inevitable mouse movement during the weighing process. The expression of CD31 in solid tumors in xenograft (f) and implantation metastasis model (g) was detected by IHC, and the right scatter plot indicated the CD31 positive area and density in each slice calculated by Image-Pro Plus 6.0. In (c), when the tumor size in the SC + Vc high group was compared to that in the SC or SC + Vc low group. In the right scatter plot of (f) and (g), means when the SC + Vc high group was compared to the SC or SC + Vc low group, and the IP + Vc high group was compared to the IP or IP + Vc low group . Xenograft groups: SC (Saline), SC + Vc low, and SC + Vc high; intraperitoneal implantation metastasis groups: IP (Saline), IP + Vc low, and IP + Vc high.

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