High-Dose Vitamin C Tends to Kill Colorectal Cancer with High MALAT1 Expression

Figure 3

Vitamin C induces a stable downregulation of MALAT1 in CRC in vitro and in vivo. (a) The relative expression of seven lncRNAs was detected by qPCR after LS174T was treated with 5 mM Vc. The relative expression of the lncRNA profile was detected in solid tumor tissues acquired from models of xenograft (b) and implantation metastasis (c). (d) The relative expression of MALAT1 was detected by qPCR after LS174 T was treated with different doses of Vc as final verification. In (a), when the expression of different lncRNAs in 5 mM Vc was compared to that in 0 mM group. In (b), and when the expression of different lncRNAs in the SC + Vc high group was compared to that in the SC group. In (c), when the expression of different lncRNAs in the IP + Vc high group was compared to that in the IP group. In (d), when the expression of MALAT1 in 1, 5, 10, and 20 mM groups was compared to that in 0 mM group.

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