Patterns of Anthracycline-Based Chemotherapy-Induced Adverse Drug Reactions and Their Impact on Relative Dose Intensity among Women with Breast Cancer in Ethiopia: A Prospective Observational Study

Table 1

Sociodemographic and clinical characteristics of women with breast cancer on AC and AC-T chemotherapy at TASH, from January 1 to September 30, 2017 GC, N = 146.

	Category	N (%)	Mean ± SD
Age (year)	20–34	30 (20.5)	42.2 ± 11.5
	35–49	76 (52.1)
	50–64	31 (21.2)
	≥65	9 (6.2)
Body mass index (BMI) (Kg·m^−2)	<18.5	14 (9.6)	25.2 ± 10.32
	18.5–24.99	74 (50.7)
	25–29.99	30 (23.3)
	≥30	24 (16.4)
Body surface area (m^2)	1–1.49	31 (21.2)	1.6 ± 0.19
	1.5–1.99	110 (75.3)
	≥2	5 (3.4)
Chemotherapy cycles	4 cycles	46 (31.5)	Median = 8 cycles
	6 cycles	25 (17.1)
	8 cycles	75 (51.4)
Histological classification	Ductal	131 (89.7)
	Lobular	6 (4.1)
	Mixed	3 (2.1)
	Papillary	3 (2.1)
	Mucinous	2 (1.4)
	Metaplastic	1 (0.7)
Stage	I	6 (4.1)
	II	48 (32.8)
	III	64 (43.8)
	IV	28 (19.2)
Comorbidity	Yes	22 (15.1)
	No	124 (84.9)
ECOG performance	0	3 (2.1)
	I	135 (92.5)
	II	5 (3.4)
	III	3 (2.1)
Marital status	Single	10 (6.7)
	Married	98 (67.1)
	Divorced/widowed	38 (26.2)
Educational status	Illiterate	58 (39.7)
	Semiliterate	63 (43.2)
	Literate	25 (17.1)
Baseline laboratory values	Mean ± SD		Normal range
SCr (mg/dl)	1.0 (0.18)		0.5–1.2
AST (U/L)	27.7 (21.87)		≤40
ALT (U/L)	23.5 (29.25)		≤40
ALP (U/L)	227.9 (212.11)		≤270
WBC (10^3/mm^3)	7.3 (2.40)		4–10
Hgb (gm/dL)	13.9 (1.36)		12–16
PLT (10^3/mm^3)	314.1 (110.58)		150–450
ANC (10^3/mm^3)	4.1 (1.97)		2–7.8
Lympho (10^3/mm^3)	2.4 (0.80)		1.2–3.4

Semiliterate = those who attended elementary/high school or grade 1–12^th; literate = those who had a college diploma/degree; and others are considered illiterate. Normal range is a reference range/value which is expected for healthy women. AC, Adriamycin-cyclophosphamide; AC ⟶ T, Adriamycin-cyclophosphamide ⟶ paclitaxel; ALP, alkaline phosphatase; ALT, alanine aminotransferase; ANC, absolute neutrophil count; AST, aspartate aminotransferase; BMI, body mass index; BSA, body surface area; ECOG, Eastern Cooperative Oncology Group; GC, Gregorian Calendar; Hgb, hemoglobin; Lympho, lymphocytes; PLT, platelet count; SCr, serum creatinine; SD, standard deviation; TASH, Tikur Anbessa Specialized Hospital; WBC, white blood cell count.