Cell-Permeable Bak BH3 Peptide Induces Chemosensitization of Hematologic Malignant Cells

Figure 5

The combination of cell-permeable BH3 peptides enhances chemotherapy sensitivity in hematologic malignant cell lines. Ramos and CCRF-CEM cells were incubated for 6 hrs with 20 μM of the PEKT, PET, and KT peptides and 5 μM of the X and PEX peptides and the combination of PEXT and PEX. Vincristine 80 nM was the chemotherapeutic agent. In both cases, cell viability was determined with MTT assays. The graphs represent the values of three independent assays. The ANOVA test was performed with Bonferroni post hoc analysis to establish the difference between groups.  < 0.05.