Genomic Profiling and Functional Analysis of let-7c miRNA-mRNA Interactions Identify SOX13 to Be Involved in Invasion and Progression of Pancreatic Cancer

<div>(a) Expression of miR-let-7c potential gene target SOX13 in adjacent normal pancreas and PDAC tumour tissue. (b) SOX13 mRNA significantly higher in TCGA pancreatic tumour compared with normal tissue. (c) Kaplan–Meier overall survival of TCGA pancreatic cancer patient’s cut-off into low vs. high SOX13 mRNA expression. (d) Kaplan–Meier overall survival of independent cohort of pancreatic cancer patients dichotomized into negative vs. positive SOX13 protein expression by IHC.</div>

Journal of Oncology

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Figure 4: Genomic Profiling and Functional Analysis of let-7c miRNA-mRNA Interactions Identify SOX13 to Be Involved in Invasion and Progression of Pancreatic Cancer

Figure 4 | Genomic Profiling and Functional Analysis of let-7c miRNA-mRNA Interactions Identify SOX13 to Be Involved in Invasion and Progression of Pancreatic Cancer 